Immunosuppression alters disease severity in juvenile Batten disease mice.

Seehafer SS; Ramirez Montealegre D; Wong AM; Chan CH; Castaneda J; Horak M; Ahmadi SM; Lim MJ; Cooper JD; Pearce DA

首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Immunosuppression alters disease severity in juvenile Batten disease mice.

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Immunosuppression alters disease severity in juvenile Batten disease mice.

机译：免疫抑制改变了青少年巴滕病小鼠的疾病严重程度。

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Autoantibodies to brain proteins are present in Juvenile Neuronal Ceroid Lipofuscinosis (Batten disease) patients and in the Cln3-/- mouse model of this disease, suggesting an autoimmune component to pathogenesis. Using genetic or pharmaceutical approaches to attenuate this immune response in Cln3-/- mice, we demonstrate decreased neuroinflammation, decreased deposition of immunoglobulin G in the brain and protection of vulnerable neuron populations. Moreover, immune suppression results in a significant improvement in motor performance providing for the first plausible therapeutic approach for juvenile Batten disease.

机译：脑蛋白的自身抗体存在于青少年神经元类脂脂肪增多症（巴顿病）患者和该疾病的Cln3-/-小鼠模型中，提示其发病机理是自身免疫成分。使用遗传或药物方法来减弱Cln3-/-小鼠中的这种免疫反应，我们证明了神经炎症减少，免疫球蛋白G在大脑中的沉积减少以及对易受伤害的神经元群体的保护。此外，免疫抑制导致运动能力的显着改善，为少年巴顿病提供了第一种可行的治疗方法。

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《Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology》 |2011年第2期|共4页
作者
Seehafer SS; Ramirez Montealegre D; Wong AM; Chan CH; Castaneda J; Horak M; Ahmadi SM; Lim MJ; Cooper JD; Pearce DA;
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正文语种 eng
中图分类神经病学;
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1. Immunosuppression alters disease severity in juvenile Batten disease mice. [J] . Seehafer SS, Ramirez Montealegre D, Wong AM, Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology . 2011,第1a2期

机译：免疫抑制改变了青少年巴滕病小鼠的疾病严重程度。
2. Genotype does not predict severity of behavioural phenotype in juvenile neuronal ceroid lipofuscinosis (Batten disease) [J] . HEATHER R ADAMS, CHRISTOPHER A BECK, ERIKA LEVY, Developmental Medicine & Child Neurology . 2010,第7期

机译：基因型不能预测幼年神经元类固醇脂褐变病（巴顿病）的行为表型的严重性
3. Genotype does not predict severity of behavioural phenotype in juvenile neuronal ceroid lipofuscinosis (Batten disease). [J] . Adams HR, Beck CA, Levy E, Developmental Medicine and Child Neurology . 2010,第7期

机译：基因型不能预测青少年神经元类固醇脂褐变病（巴顿病）的行为表型的严重性。
4. Intense immunosuppression and stem cell transplantation in severe autoimmune diseases [C] . Lisukov, I.A. . 2000

机译：严重自身免疫疾病中的强免疫抑制和干细胞移植
5. Photobiomodulation with 670nm near infrared light treatment ameliorates disease severity of MOG35-55 induced experimental autoimmune encephalomyelitis (EAE) in C57BL/6 mice. [D] . Muili, Kamaldeen Ayodele. 2010

机译：670nm近红外光处理的光生物调节改善了C57BL / 6小鼠MOG35-55诱导的实验性自身免疫性脑脊髓炎（EAE）的疾病严重程度。
6. Immunosuppression alters disease severity in juvenile Batten disease mice [O] . Sabrina S. Seehafer, Denia Ramirez-Montealegre, Andrew MS Wong, -1

机译：免疫抑制改变了少年鳞型疾病小鼠的疾病严重程度
7. Immunosuppression alters disease severity in juvenile Batten disease mice [O] . Seehafer, Sabrina S., Ramirez-Montealegre, Denia, Wong, Andrew M. S., 2011

机译：免疫抑制改变幼年巴滕病小鼠的疾病严重程度
8. Influence of Lymphohematopoietic Disease in Altering Radiation Induced Cancer Sensitivity in Mice. [R] . Cain, G. R. 1983

机译：淋巴造血系统疾病对改变小鼠放射性癌症敏感性的影响。

Immunosuppression alters disease severity in juvenile Batten disease mice.

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