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首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Natalizumab therapy decreases surface expression of both VLA-heterodimer subunits on peripheral blood mononuclear cells.
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Natalizumab therapy decreases surface expression of both VLA-heterodimer subunits on peripheral blood mononuclear cells.

机译：纳他珠单抗疗法可降低外周血单核细胞上两个VLA-异二聚体亚基的表面表达。

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摘要

Natalizumab interferes with immune cell migration into the central nervous system via blocking the alpha-4 subunit of very-late activation antigen-4 (VLA-4). Occurrence of rare but serious progressive multifocal leukoencephalopathy during prolonged natalizumab therapy of multiple sclerosis (MS) calls for a more detailed understanding of potential coeffects. We longitudinally studied alpha-4 and beta-1 surface levels on blood cells from 18 MS patients by flow cytometry. Expectedly, detectability of natalizumab-blocked alpha-4 was diminished on all investigated cell subsets. In addition, we report a concurrent and significant decrease of beta-1 surface levels on T-cells, B-cells, natural killer cells, and natural killer T cells, but not on monocytes. Uncovering secondary effects of natalizumab is mandatory to increase safety in MS therapy.
机译：纳他珠单抗通过阻断非常晚期的活化抗原4（VLA-4）的α-4亚基来干扰免疫细胞向中枢神经系统的迁移。长期使用那他珠单抗治疗多发性硬化症（MS）时，罕见但严重的进行性多灶性白质脑病的发生，需要对潜在的协同效应有更详细的了解。我们通过流式细胞仪对18名MS患者的血细胞上的α-4和β-1表面水平进行了纵向研究。预期，在所有研究的细胞亚群中，那他珠单抗阻断的α-4的可检测性均降低了。另外，我们报告了T细胞，B细胞，自然杀伤细胞和自然杀伤T细胞上β-1表面水平的同时并显着下降，但单核细胞上却没有。必须发现那他珠单抗的次要作用以增加MS治疗的安全性。

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