The U937 macrophage cell line expresses enzymatically active L-Dopa decarboxylase.

Kokkinou I; Fragoulis EG; Vassilacopoulou D

首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >The U937 macrophage cell line expresses enzymatically active L-Dopa decarboxylase.

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The U937 macrophage cell line expresses enzymatically active L-Dopa decarboxylase.

机译：U937巨噬细胞细胞系表达具有酶活性的L-Dopa脱羧酶。

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In the present study we demonstrate that enzymatically active l-Dopa decarboxylase (DDC) is expressed in U937 cells, an important model of human macrophage function. The mRNA coding for the enzyme was found to be of the neural-type. DDC was detected in both the soluble and membrane fractions. The active molecule is released from the membrane fraction in the absence of detergent. Furthermore, exposure of U937 cells to carbidopa and dopamine considerably affected cell viability. The expression of enzymatically active DDC shows the endogenous production of dopamine in U937 cells and raises new questions about the enzyme's involvement in immune responses.

机译：在本研究中，我们证明了具有酶活性的I-多巴脱羧酶（DDC）在U937细胞中表达，U937细胞是人类巨噬细胞功能的重要模型。发现编码该酶的mRNA是神经型的。在可溶性和膜级分中均检测到DDC。在没有去污剂的情况下，活性分子从膜部分中释放出来。此外，U937细胞暴露于卡比多巴和多巴胺会大大影响细胞活力。具有酶活性的DDC的表达显示了U937细胞中内源性多巴胺的产生，并提出了有关该酶参与免疫反应的新问题。

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《Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology》 |2009年第2期|共8页
作者
Kokkinou I; Fragoulis EG; Vassilacopoulou D;
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正文语种 eng
中图分类神经病学与精神病学;医学免疫学;
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1. The U937 macrophage cell line expresses enzymatically active L-Dopa decarboxylase. [J] . Kokkinou I, Fragoulis EG, Vassilacopoulou D Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology . 2009,第1a2期

机译：U937巨噬细胞细胞系表达具有酶活性的L-Dopa脱羧酶。
2. The U937 macrophage cell line expresses enzymatically active L-Dopa decarboxylase. [J] . Kokkinou I, Fragoulis EG, Vassilacopoulou D Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology . 2009,第1a2期

机译：U937巨噬细胞系表达酶活性L-DOPA脱羧酶。
3. The U937 macrophage cell line expresses enzymatically active L-Dopa decarboxylase. [J] . Kokkinou I, Fragoulis EG, Vassilacopoulou D Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology . 2009,第1a2期

机译：U937巨噬细胞系表达酶活性L-DOPA脱羧酶。
4. Cyclic Biaxial Strain Affects U937 Macrophage-like Morphology And Enzymatic Activities [C] . L.A. Matheson, G.N. Maksym, J.P. Santerre, Society for Biomaterials Transactions 30th Annual Meeting & Exposition vol.28: New Applications and Technologies . 2005

机译：循环双轴应变影响U937巨噬细胞样形态和酶活性。
5. I. A new suicide trigger for L-lysine decarboxylase. II. Second generation in situ enzymatic screening (ISES): Predicting enantioselectivity. [D] . Karukurichi, Kannan R. 2006

机译：I.L-赖氨酸脱羧酶的新自杀触发剂。二。第二代原位酶筛（ISES）：预测对映选择性。
6. High level expression in Escherichia coli of soluble enzymatically active schistosomal hypoxanthine/guanine phosphoribosyltransferase and trypanosomal ornithine decarboxylase. [O] . S P Craig 3rd, L Yuan, D A Kuntz, 1991

机译：可溶性酶活性的血吸虫次黄嘌呤/鸟嘌呤磷酸核糖基转移酶和锥虫鸟氨酸鸟氨酸脱羧酶在大肠杆菌中的高水平表达。
7. High level expression in Escherichia coli of soluble, enzymatically active schistosomal hypoxanthine/guanine phosphoribosyltransferase and trypanosomal ornithine decarboxylase. [O] . Craig, S P, Yuan, L, Kuntz, D A, 1991

机译：可溶性，酶活性的血吸虫次黄嘌呤/鸟嘌呤磷酸核糖基转移酶和锥虫鸟氨酸鸟氨酸脱羧酶在大肠杆菌中的高水平表达。

The U937 macrophage cell line expresses enzymatically active L-Dopa decarboxylase.

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