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首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Endogenous remyelination is induced by transplant rejection in a viral model of multiple sclerosis.
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Endogenous remyelination is induced by transplant rejection in a viral model of multiple sclerosis.

机译：在多发性硬化症的病毒模型中，移植排斥导致内源性髓鞘再生。

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Human embryonic stem cell-derived oligodendrocyte progenitors (OPCs) were transplanted into mice persistently infected with the neurotropic JHM strain of mouse hepatitis virus with established demyelination. Engrafted cells did not survive past 2 weeks following transplantation despite treatment with high dose cyclosporine A. While T cell infiltration into the CNS was dampened, elevated numbers of macrophage/microglia and endogenous OPCs were evident surrounding the implantation site and this was associated with increased remyelination. These data suggest that remyelination was initiated by the local response to xenograft transplantation. These findings illustrate the complexities of OPC transplantation into areas of robust immune-mediated pathology.
机译：将人类胚胎干细胞衍生的少突胶质细胞祖细胞（OPC）移植到小鼠中，该小鼠持续感染了已建立脱髓鞘的小鼠肝炎病毒的嗜神经性JHM株。尽管用大剂量环孢霉素A进行治疗，但移植后的细胞仍无法存活超过2周。尽管抑制了T细胞向CNS的浸润，但植入位点周围的巨噬细胞/小胶质细胞和内源性OPC数量明显增加，这与髓鞘再生增加有关。这些数据表明，髓鞘再生是由对异种移植的局部反应引起的。这些发现说明了OPC移植到强力免疫介导的病理学区域的复杂性。

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