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首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Effect of carbamylated erythropoietin on major histocompatibility complex expression and neural differentiation of human neural stem cells.
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Effect of carbamylated erythropoietin on major histocompatibility complex expression and neural differentiation of human neural stem cells.

机译：氨基甲酸酯化的促红细胞生成素对人神经干细胞主要组织相容性复合物表达和神经分化的影响。

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摘要

The expression of major histocompatibility complex (MHC) on human neural stem cells (hNSCs) is tightly related to the fate of these cells in transplantation, therefore strategies to relieve rejection and promote graft survival are necessary to be applied. This study investigated the effect of carbamylated erythropoietin (CEPO) on MHC expression and differentiation of hNSCs with or without IFN-gamma incubation. Results showed that low levels of MHC molecules were expressed on hNSCs and increased by IFN-gamma. CEPO enhanced MHC-I antigens in both proliferative and differentiated hNSCs, but decreased MHC-II antigens in differentiated hNSCs and those cells exposed to IFN-gamma. Furthermore, CEPO promoted neural differentiation of hNSCs and outgrowth of neurites. Western blot analysis revealed activation of Stat3, Stat5 and Akt during these processes. These results suggest that CEPO may have immunoregulatory function in hNSCs besides its neuroprotection.
机译：主要的组织相容性复合物（MHC）在人神经干细胞（hNSCs）上的表达与这些细胞在移植中的命运密切相关，因此有必要采用缓解排斥反应并促进移植物存活的策略。这项研究调查了氨基甲酸酯化的促红细胞生成素（CEPO）在有或没有IFN-γ孵育的情况下对hNSCs MHC表达和分化的影响。结果表明，低水平的MHC分子在hNSCs上表达，并被IFN-γ增加。 CEPO在增殖和分化的hNSC中均增强了MHC-I抗原，但在分化的hNSC和暴露于IFN-γ的那些细胞中均降低了MHC-II抗原。此外，CEPO促进了hNSCs的神经分化和神经突的生长。蛋白质印迹分析揭示了在这些过程中Stat3，Stat5和Akt的激活。这些结果表明，CEPO除了具有神经保护作用外，还可能在hNSC中具有免疫调节功能。

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