Strain-specific BDNF expression of rat primary astrocytes.

Wei R; Lin CM; Tu YY

首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Strain-specific BDNF expression of rat primary astrocytes.

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Strain-specific BDNF expression of rat primary astrocytes.

机译：大鼠原代星形胶质细胞的菌株特异性BDNF表达。

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By producing brain-derived neurotrophic factor (BDNF), astrocytes play a role in disease resistance. This study was undertaken to investigate whether primary astrocytes derived from LEW/N and F344/N rats differentially express BDNF. LEW/N astrocytes expressed more BDNF mRNA and protein than F344/N astrocytes in basal and valproic acid (VPA)-stimulated conditions. VPA suppresses HDAC enzyme activity without affecting HDAC gene and protein expression in astrocytes of both strains. Blockade of TrkB receptors resulted in similar fold decreases in basal BDNF mRNA levels between two strains. The results suggest that inhibition of HDAC activity and BDNF-TrkB autocrine loop are involved in regulation of astrocytic BDNF transcription, whereas the mechanisms for elevated constitutive gene BDNF expression of LEW/N astrocytes remain to be investigated.

机译：通过产生脑源性神经营养因子（BDNF），星形胶质细胞在抗病性中发挥作用。进行了这项研究以调查从LEW / N和F344 / N大鼠衍生的原代星形胶质细胞是否差异表达BDNF。在基础和丙戊酸（VPA）刺激的条件下，LEW / N星形胶质细胞比F344 / N星形胶质细胞表达更多的BDNF mRNA和蛋白。 VPA抑制HDAC酶的活性，而不影响两种菌株的星形胶质细胞中的HDAC基因和蛋白质表达。 TrkB受体的封锁导致两个菌株之间基础BDNF mRNA水平的相似降低。结果表明，HDAC活性和BDNF-TrkB自分泌环的抑制与星形细胞BDNF转录的调控有关，而LEW / N星形胶质细胞组成型基因BDNF表达升高的机制尚待研究。

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《Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology》 |2010年第2期|共9页
作者
Wei R; Lin CM; Tu YY;
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正文语种 eng
中图分类神经病学与精神病学;医学免疫学;
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机译：大鼠原代星形胶质细胞的菌株特异性BDNF表达。
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Strain-specific BDNF expression of rat primary astrocytes.

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