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首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Cerebrospinal fluid levels of BAFF and APRIL in untreated multiple sclerosis.
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Cerebrospinal fluid levels of BAFF and APRIL in untreated multiple sclerosis.

机译：未经治疗的多发性硬化症中脑脊液BAFF和APRIL的水平。

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OBJECTIVE AND SUBJECTS: To examine in vivo levels of BAFF (B-cell activating factor of the tumor necrosis factor family) and APRIL (a proliferation-inducing ligand) in both the cerebrospinal fluid (CSF) and serum of 30 naive MS patients and 79 subjects affected by acute or chronic inflammatory or non-inflammatory neurological diseases. DESIGN: Case-control study. RESULTS: No difference among groups was evidenced in serum BAFF or APRIL levels. By contrast, CSF levels of BAFF in MS (mean 144.3 pg/ml+/-141.2), although not significantly different from those observed in NIND (164.2 pg/ml+/-92.0), acute peripheral OIND (243.1 pg/ml+/-139.0) or chronic OIND (240.2 pg/ml+/-122.5), were significantly higher in acute central OIND patients (1274.0 pg/ml+/-803.8; p<0.001 vs. all groups). Similarly, CSF APRIL levels in MS (1541.0 pg/ml+/-1071.0), NIND (2629.0 pg/ml+/-1669.0), acute peripheral OIND (2834.0 pg/ml+/-1118.) or chronic OIND (2764.0 pg/ml+/-659.7) were not significantly different, while they were significantly higher in acute central OIND (6218.0 pg/ml+/-3790.0; p<0.001 vs. MS and NIND; and p<0.05 vs. acute peripheral OIND). CONCLUSIONS: Our results strongly suggest that further investigation is warranted to elucidate the role of BAFF and APRIL in MS and that serum levels of BAFF and APRIL do not reflect CSF levels.
机译：目的和研究对象：30例初诊MS患者和79例脑脊髓液（CSF）和血清中的BAFF（肿瘤坏死因子家族的B细胞激活因子）和APRIL（一种增殖诱导配体）的体内水平受急性或慢性炎性或非炎性神经系统疾病影响的受试者。设计：病例对照研究。结果：各组之间血清BAFF或APRIL水平无明显差异。相比之下，MS中BAFF的脑脊液水平（平均144.3 pg / ml +/- 141.2），尽管与NIND（164.2 pg / ml +/- 92.0），急性外周OIND（243.1 pg / ml +/- 139.0）中观察到的无显着差异）或慢性OIND（240.2 pg / ml +/- 122.5）在急性中枢性OIND患者中明显更高（1274.0 pg / ml +/- 803.8;与所有组相比p <0.001）。同样，MS（1541.0 pg / ml +/- 1071.0），NIND（2629.0 pg / ml +/- 1669.0），急性外周OIND（2834.0 pg / ml +/- 1118。）或慢性OIND（2764.0 pg / ml + /）中的CSF APRIL水平-659.7）没有显着差异，而在急性中枢OIND中则显着较高（6218.0 pg / ml +/- 3790.0;与MS和NIND相比p <0.001;与急性外周OIND相比p <0.05）。结论：我们的结果强烈表明，有必要进一步研究以阐明BAFF和APRIL在MS中的作用，并且BAFF和APRIL的血清水平不能反映CSF水平。

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