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首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Increase of Ki-67+ natural killer cells in multiple sclerosis patients treated with interferon-beta and interferon-beta combined with low-dose oral steroids.
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Increase of Ki-67+ natural killer cells in multiple sclerosis patients treated with interferon-beta and interferon-beta combined with low-dose oral steroids.

机译：干扰素-β和干扰素-β联合低剂量口服类固醇治疗的多发性硬化症患者中Ki-67 +自然杀伤细胞增加。

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摘要

Interferon-beta (IFN-beta) is known to expand regulatory CD56(bright) natural killer (NK) cells in multiple sclerosis (MS). In this cross-sectional study we show that MS patients treated with IFN-beta alone or in combination with low-dose prednisolone displayed increased proportion of all NK cell subsets in the active phase of the cell cycle (Ki-67+). There was no difference in NK cell apoptosis markers. In vitro experiments showed that both IFN-beta and IFN-beta in combination with corticosteroids increased the proportion of Ki-67(+) NK cells. This study, although limited, shows that treatment with IFN-beta affects NK cell cycle without altering NK cell apoptosis in MS patients.
机译：已知干扰素-β（IFN-β）可在多发性硬化症（MS）中扩展调节性CD56（亮）自然杀伤（NK）细胞。在这项横断面研究中，我们显示，单独接受IFN-β或与低剂量泼尼松龙联合治疗的MS患者，在细胞周期活跃期（Ki-67 +）中显示所有NK细胞亚群的比例增加。 NK细胞凋亡标记物无差异。体外实验表明，IFN-β和IFN-β联合皮质类固醇均可增加Ki-67（+）NK细胞的比例。这项研究尽管有局限性，但表明用IFN-β治疗可影响NK细胞周期而不会改变MS患者的NK细胞凋亡。

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