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首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >RORC and Foxp3 axis in cerebrospinal fluid of patients with neuro-Behcet's disease.
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RORC and Foxp3 axis in cerebrospinal fluid of patients with neuro-Behcet's disease.

机译：神经贝塞特氏病患者脑脊液中的RORC和Foxp3轴。

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摘要

Neurological manifestations are present in 5% to 30% of patients with Behcet's disease (BD). Neuro-Behcet's Disease (NBD) is hypothetically caused by T helper (Th) cells, which development is dependent on the expression of lineage-specific transcription factors. Cerebrospinal fluid (CSF) mRNA expression of TBX21, GATA3, RORC, FOXP3 and EBI3 were assessed in 18 NBD patients and 26 controls disease [16 noninflammatory neurological disease (NIND) and 10 headache attributed to Behcet's disease (HaBD)]. Expression of TBX21 (Th1), RORC (Th17) and Foxp3 (Treg) were increased in NBD patients compared to HaBD and NIND patients. EBI3 and Th2-associated GATA3 expressions were found to be decreased (P<0.0001 and P<0.0001) in NBD patients. Analysis of transcription factor ratios, revealed an increase in the RORC/FOXP3 and TBX21/GATA3 ratios in NBD patients (P<0.0001; P<0.0003). Our findings indicate that both Th1 and Th17 mRNA expressions involving a possible impairment of Treg cells. This might play a role in CSF-NBD inflammation, permitting activation of harmful T cell subpopulations. The TBX21/GATA3 and RORC/FOXP3 ratios dysregulations in NBD are consistent with those reported in other inflammatory diseases and indicating the plasticity existing between Th1, Th17 and Treg cells during inflammation.
机译：白塞氏病（BD）患者中有5％至30％存在神经系统症状。假设神经贝塞特病（NBD）由T辅助（Th）细胞引起，其发展取决于谱系特异性转录因子的表达。在18例NBD患者和26例对照疾病[16例非炎症性神经疾病（NIND）和10例归因于Behcet病（HaBD）的头痛]中评估了TBX21，GATA3，RORC，FOXP3和EBI3的脑脊液（CSF）mRNA表达。与HaBD和NIND患者相比，NBD患者中TBX21（Th1），RORC（Th17）和Foxp3（Treg）的表达增加。在NBD患者中，发现EBI3和Th2相关的GATA3表达下降（P <0.0001和P <0.0001）。转录因子比率的分析显示，NBD患者的RORC / FOXP3和TBX21 / GATA3比率增加（P <0.0001; P <0.0003）。我们的发现表明Th1和Th17 mRNA表达均涉及Treg细胞的可能损伤。这可能在CSF-NBD炎症中起作用，从而激活有害T细胞亚群。 NBD中的TBX21 / GATA3和RORC / FOXP3比率失调与其他炎性疾病中报道的失调一致，表明炎症期间Th1，Th17和Treg细胞之间存在可塑性。

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