• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Depletion of Ly6G/C(+) cells ameliorates delayed cerebral vasospasm in subarachnoid hemorrhage.
【24h】

Depletion of Ly6G/C(+) cells ameliorates delayed cerebral vasospasm in subarachnoid hemorrhage.

机译：Ly6G / C（+）细胞的耗竭可改善蛛网膜下腔出血中延迟的脑血管痉挛。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND: The etiology of delayed cerebral vasospasm (DCV) after aneurysmal subarachnoid hemorrhage (SAH) has remained elusive. Growing evidence supports a role for inflammation in the pathogenesis of DCV. We showed that CSF neutrophils predict which patients will develop DCV. METHODS: We evaluated a murine model of SAH to test the hypothesis that myeloid cells are required for the cerebral damage associated with DCV. RESULTS: SAH was associated with decreased middle cerebral artery caliber on day 1 which normalized at day 3 and recurred at day 6. In addition, behavioral testing with a Barnes maze showed executive dysfunction that progressively worsened after the seventh day post hemorrhage. To test the role of innate immune responses, we administrated a myeloid cell-depleting monoclonal antibody against Ly6G/C prior to experimental SAH. Myeloid cell depletion ameliorated angiographic vasospasm measured by MCA vessel caliber and normalized behavioral testing. CONCLUSION: Our findings support the role of Ly6G/C(+) cells in the development of DCV after SAH and suggest that immune modulation of neutrophils or other Ly6G/C(+) cells may be a strategy for the prevention of DCV.
机译：背景：动脉瘤性蛛网膜下腔出血（SAH）后迟发性脑血管痉挛（DCV）的病因仍然难以捉摸。越来越多的证据支持炎症在DCV的发病机理中的作用。我们表明，CSF中性粒细胞可预测哪些患者会发展为DCV。方法：我们评估了SAH的鼠模型，以检验髓样细胞是与DCV相关的脑损伤所必需的假设。结果：SAH与第1天恢复正常并在第6天复发的第1天大脑中动脉口径下降有关。此外，用Barnes迷宫进行的行为测试显示执行功能障碍在出血后第七天逐渐恶化。为了测试先天免疫应答的作用，我们在实验SAH之前施用了针对Ly6G / C的耗竭骨髓细胞的单克隆抗体。通过MCA血管口径和规范化的行为测试测量，骨髓细胞耗竭可改善血管造影血管痉挛。结论：我们的发现支持SAH后Ly6G / C（+）细胞在DCV发生中的作用，并建议中性粒细胞或其他Ly6G / C（+）细胞的免疫调节可能是预防DCV的策略。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号