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首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Evolution of neuroendocrine thymus: studies on POMC-derived peptides, cytokines and apoptosis in lower and higher vertebrates.
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Evolution of neuroendocrine thymus: studies on POMC-derived peptides, cytokines and apoptosis in lower and higher vertebrates.

机译：神经内分泌胸腺的进化：POMC衍生的肽，细胞因子和高等脊椎动物中细胞凋亡的研究。

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In previous papers, we showed that neuroendocrine cells reactive to anti-POMC-derived peptides and cytokines are present in the thymus of a fish and an anuran amphibian. Here we report that this phenomenon is general, as neuroendocrine cells positive to anti-POMC-derived peptides (ACTH, beta-endorphin, alpha-MSH) and cytokines (IL-1 alpha, IL-2, IL-6, TNF-alpha) are also present in the thymus of chicken and rat. However, the number and the intrathymic localization and distribution of these cells varies in the different species examined. An analysis of apoptotic cells or cells involved in apoptosis, such as interdigitating cells and macrophages, in fish, frog, chicken and rat thymus, using an immunocytochemical method and anti-DNA mAb conjugated with peroxidase (anti-DNA-POD), showed that cells positive to anti-DNA-POD mAb are present in the same thymic areas in which POMC-derived peptides and cytokines were found. In conclusion, these data on apoptotic cells in the thymus of lower and higher vertebrates are compatible with the hypothesis that neuroendocrine cells might play a role in the selection and apoptosis of thymic lymphocytes, a phenomenon which could vary slightly in different species and taxa.
机译：在以前的论文中，我们显示了在鱼类和无脊椎动物两栖动物的胸腺中存在与抗POMC衍生的肽和细胞因子发生反应的神经内分泌细胞。在这里，我们报告这种现象是普遍的，因为对抗POMC衍生的肽（ACTH，β-内啡肽，α-MSH）和细胞因子（IL-1 alpha，IL-2，IL-6，TNF-alpha）呈阳性的神经内分泌细胞）也存在于鸡和大鼠的胸腺中。但是，这些细胞的数量和胸腺内定位和分布在所检查的不同物种中有所不同。使用免疫细胞化学方法和过氧化物酶结合的抗DNA mAb（anti-DNA-POD）分析鱼，蛙，鸡和大鼠胸腺中的凋亡细胞或参与凋亡的细胞，例如交叉指细胞和巨噬细胞，表明：对抗DNA-POD mAb呈阳性的细胞存在于同一胸腺区域，在该区域中发现了POMC衍生的肽和细胞因子。总之，这些有关低等和高级脊椎动物胸腺中凋亡细胞的数据与以下假设相符：神经内分泌细胞可能在胸腺淋巴细胞的选择和凋亡中起作用，这种现象在不同的​​物种和分类群中可能会略有不同。

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