• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Identification of an epitope derived from human proteolipid protein that can induce autoreactive CD8+ cytotoxic T lymphocytes restricted by HLA-A3: evidence for cross-reactivity with an environmental microorganism.
【24h】

Identification of an epitope derived from human proteolipid protein that can induce autoreactive CD8+ cytotoxic T lymphocytes restricted by HLA-A3: evidence for cross-reactivity with an environmental microorganism.

机译：鉴定可诱导受HLA-A3限制的自身反应性CD8 +细胞毒性T淋巴细胞的人蛋白脂蛋白衍生的表位：与环境微生物交叉反应的证据。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The demyelination process that occurs in the central nervous system (CNS) of patients with multiple sclerosis (MS) is in part due to an inflammatory response in which CD4+ and CD8+ T cells and macrophages infiltrate white matter. In this study, we have identified a peptide sequence derived from the CNS-specific myelin protein proteolipid protein (PLP) which could bind to HLA-A3 and induce a HLA-A3-restricted CD8+ CTL response from HLA-A3+ donors. These PLP peptide-specific CTL could lyse HLA-A3+ target cells pulsed with a homologous peptide derived from the CRM1 protein of Saccharomyces cerevisae. These findings demonstrate the immunogenic potential of a PLP-derived peptide for generation of autoreactive HLA-A3-restricted CD8+ CTL, and further show that these CTL can be activated by a peptide derived from a common environmental microorganism.
机译：多发性硬化症（MS）患者的中枢神经系统（CNS）中发生的脱髓鞘过程部分归因于炎症反应，其中CD4 +和CD8 + T细胞和巨噬细胞浸润了白质。在这项研究中，我们确定了源自CNS特异性髓磷脂蛋白蛋白脂蛋白（PLP）的肽序列，该肽序列可与HLA-A3结合并诱导HLA-A3 +供体的HLA-A3限制性CD8 + CTL反应。这些PLP肽特异性CTL可以裂解用源自酿酒酵母CRM1蛋白的同源肽脉冲的HLA-A3 +目标细胞。这些发现证明了PLP衍生的肽在产生自身反应性HLA-A3限制性CD8 + CTL方面的免疫原性，并且进一步表明这些CTL可以被源自普通环境微生物的肽激活。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号