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首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Cerebellar degeneration associated with mGluR1 autoantibodies as a paraneoplastic manifestation of prostate adenocarcinoma
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Cerebellar degeneration associated with mGluR1 autoantibodies as a paraneoplastic manifestation of prostate adenocarcinoma

机译：与mGluR1自身抗体相关的小脑变性是前列腺腺癌的副肿瘤表现

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摘要

Subacute cerebellar degeneration associated with metabotropic glutamate receptor type 1 (mGluR1) autoantibodies is an uncommon syndrome known to be part of the spectrum of paraneoplastic cerebellar degenerations associated with neuronal autoantibodies. We describe a patient with prostate adenocarcinoma who developed a subacute cerebellar ataxia. Autoantibodies specific to mGluR1 were detected in patient's serum and cerebrospinal fluid (CSF). Immunohistochemistry analyses of patient's prostate adenocarcinoma revealed abundant mGluR1 expression in luminal acinar epithelial cells and binding of patient's IgGs to tumoral mGluR1.These findings suggest that cerebellar degeneration associated with mGluR1 antibodies can be a paraneoplastic accompaniment of prostate adenocarcinoma.
机译：与代谢型谷氨酸受体1型（mGluR1）自身抗体相关的亚急性小脑变性是一种罕见的综合征，已知是与神经元自身抗体相关的副肿瘤性小脑变性谱的一部分。我们描述了一名患有亚急性小脑共济失调的前列腺腺癌患者。在患者的血清和脑脊液（CSF）中检测到了mGluR1特异的自身抗体。对患者前列腺腺癌的免疫组织化学分析显示，mGluR1在腔腺腺上皮细胞中表达丰富，并且患者IgG与肿瘤性mGluR1结合，这些发现表明与mGluR1抗体相关的小脑变性可能是前列腺腺癌的副肿瘤伴发。

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