首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Favorable outcome of granulocyte colony-stimulating factor use in neuromyelitis optica patients presenting with agranulocytosis in the setting of rituximab
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Favorable outcome of granulocyte colony-stimulating factor use in neuromyelitis optica patients presenting with agranulocytosis in the setting of rituximab

机译:在利妥昔单抗环境中伴有粒细胞缺乏症的视神经脊髓炎患者中粒细胞集落刺激因子的使用效果良好

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摘要

Neuromyelitis optica is a severe autoimmune condition affecting the central nervous system characterized by a relapsing disease course. Rituximab is a chimeric monoclonal antibody against the protein CD20, and is one of the most utilized medications for management of this disease. A known complication of rituximab use is neutropenia. We report on two patients who developed symptomatic early-onset rituximab-induced agranulocytosis who safely received granulocyte colony-stimulating factor. Neutrophil counts recovered quickly and both patients continue to receive rituximab without further incident. (C) 2015 Elsevier B.V. All rights reserved.
机译:视神经脊髓炎是一种严重的自身免疫疾病,会影响以复发性疾病为特征的中枢神经系统。利妥昔单抗是针对蛋白CD20的嵌合单克隆抗体,是用于控制该疾病的最常用药物之一。使用利妥昔单抗的已知并发症是嗜中性白血球减少症。我们报告了两名患者,这些患者发生了有症状的利妥昔单抗早发性粒细胞缺乏症,并安全地接受了粒细胞集落刺激因子。中性粒细胞计数迅速恢复,两名患者继续接受利妥昔单抗治疗,无进一步事件。 (C)2015 Elsevier B.V.保留所有权利。

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