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首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Evidence of different mediators of central inflammation in dysfunctional and inflammatory pain - Interleukin-8 in fibromyalgia and interleukin-1 beta in rheumatoid arthritis
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Evidence of different mediators of central inflammation in dysfunctional and inflammatory pain - Interleukin-8 in fibromyalgia and interleukin-1 beta in rheumatoid arthritis

机译：功能障碍和炎症性疼痛中不同中央炎症介质的证据-纤维肌痛中白细胞介素8和类风湿关节炎中白细胞介素1β

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摘要

The purpose of this study was to relate central inflammation to autonomic activity (heart rate variability (HRV)) in patients with rheumatoid arthritis (RA) and fibromyalgia (FM). RA patients had reduced parasympathetic activity and FM patients had increased sympathetic activity compared to healthy controls. Comparisons between RA and FM showed higher cerebrospinal fluid (CSF) interleukin (1)-1 beta inversely correlated to parasympathetic activity in RA. The FM patients had higher concentrations of CSF IL-8, IL-1Ra, IL-4 and IL-10, but none of these cytokines correlated with HRV. In conclusion, we found different profiles of central cytokines, i.e., elevated IL-1 beta in inflammatory pain (RA) and elevated IL-8 in dysfunctional pain (FM). (C) 2015 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
机译：这项研究的目的是将类风湿性关节炎（RA）和纤维肌痛（FM）患者的中央炎症与自主神经活动（心率变异性（HRV））相关联。与健康对照组相比，RA患者的副交感神经活动减少，而FM患者的交感神经活动增加。 RA和FM之间的比较显示，较高的脑脊液（CSF）白介素（1）-1β与RA中的副交感神经活性呈负相关。 FM患者的脑脊液IL-8，IL-1Ra，IL-4和IL-10浓度较高，但这些细胞因子均与HRV不相关。总之，我们发现了中枢细胞因子的不同特征，即炎性疼痛（RA）中的IL-1β升高和功能障碍性疼痛（FM）中的IL-8升高。 （C）2015作者。由Elsevier B.V.发布。这是CC BY-NC-ND许可（http://creativecommons.org/licenses/by-nc-nd/4.0/）下的开放获取文章。

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