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首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Peripheral challenge with a viral mimic upregulates expression of the complement genes in the hippocampus
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Peripheral challenge with a viral mimic upregulates expression of the complement genes in the hippocampus

机译：病毒模拟的外周攻击上调了海马中补体基因的表达

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摘要

Peripheral challenge with a viral mimetic, polyinosinic-polycytidylic acid (PIC) induces hippocampal hyperexcitability in mice. Here, we characterized this hippocampal response through a whole genome transcriptome analysis. Intraperitoneal injection of PIC resulted in temporal dysregulation of 625 genes in the hippocampus, indicating an extensive genetic reprogramming. The bioinformatics analysis of these genes revealed the complement pathway to be the most significantly activated. The gene encoding complement factor B (CfB) exhibited the highest response, and its upregulation was commensurate with the development of hyperexcitability. Collectively, these results suggest that the induction of hippocampal hyperexcitability may be mediated by the alternative complement cascades. (C) 2015 Elsevier B.V. All rights reserved.
机译：用病毒模拟物多肌苷-聚胞苷酸（PIC）进行外围攻击可诱导小鼠海马过度兴奋。在这里，我们通过全基因组转录组分析来表征这种海马反应。腹膜内注射PIC导致海马中625个基因暂时失调，表明广泛的基因重编程。这些基因的生物信息学分析显示补体途径被最显着激活。编码补体因子B（CfB）的基因表现出最高的反应，其上调与过度兴奋性的发展相称。总的来说，这些结果表明，海马超兴奋性的诱导可能由替代补体级联介导。 （C）2015 Elsevier B.V.保留所有权利。

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