Co-stimulation with TNF receptor superfamily 4/25 antibodies enhances in-vivo expansion of CD4+CD25+Foxp3+T cells (Tregs) in a mouse study for active DNA A beta 42 immunotherapy

Lambracht-Washington Doris; Rosenberg Roger N.

首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Co-stimulation with TNF receptor superfamily 4/25 antibodies enhances in-vivo expansion of CD4+CD25+Foxp3+T cells (Tregs) in a mouse study for active DNA A beta 42 immunotherapy

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Co-stimulation with TNF receptor superfamily 4/25 antibodies enhances in-vivo expansion of CD4+CD25+Foxp3+T cells (Tregs) in a mouse study for active DNA A beta 42 immunotherapy

机译：在一项针对活性DNA A beta 42免疫疗法的小鼠研究中，与TNF受体超家族4/25抗体共同刺激可增强CD4 + CD25 + Foxp3 + T细胞（Tregs）的体内扩增

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The study was designed to test DNA A beta 42 immunization in mice as alternative approach for possible active immunotherapy in Alzheimer patients. As results, we found polarized Th2 immune responses, efficient A beta 42 antibody levels, and disappearance of antigen specific T cells. In-vivo TNFRSF4/25 antibody co-stimulation enhanced A beta 42 specific T cell responses with initial Th2 expansion and subsequent development of A beta 42 specific CD4 + CD25 + Foxp3 + cells. It showed that Th2 biased responses due to gene gun immunizations propagate the development of regulatory T cells. In conclusion, full-length DNA A beta 42 immunization into skin results in a regulatory response with minimal risk of inflammation and autoimmunity. (C) 2014 Elsevier B.V. All rights reserved.

机译：该研究旨在测试小鼠中的DNA A beta 42免疫，作为对阿尔茨海默病患者进行主动免疫治疗的替代方法。结果，我们发现极化的Th2免疫应答，有效的A beta 42抗体水平以及抗原特异性T细胞的消失。体内TNFRSF4 / 25抗体共同刺激可增强Aβ42特异性T细胞反应，并具有最初的Th2扩增和随后的Aβ42特异性CD4 + CD25 + Foxp3 +细胞发育。结果表明，由于基因枪免疫而引起的Th2偏向反应会促进调节性T细胞的发育。总之，对皮肤的全长DNA Aβ42免疫导致调节反应，且炎症和自身免疫风险最小。（C）2014 Elsevier B.V.保留所有权利。

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《Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology》 |2015年第null期|共10页
作者
Lambracht-Washington Doris; Rosenberg Roger N.;
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正文语种 eng
中图分类神经病学;
关键词
TNFRSF4/25 antibody co-stimulation; DNA A beta 42 immunization; Alzheimer disease; Th2/Treg differentiation; Skin immunity;

机译：TNFRSF4 / 25抗体共刺激;DNA A beta 42免疫;阿尔茨海默病;Th2 / Treg分化;皮肤免疫;

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1. Co-stimulation with TNF receptor superfamily 4/25 antibodies enhances in-vivo expansion of CD4+CD25+Foxp3+T cells (Tregs) in a mouse study for active DNA A beta 42 immunotherapy [J] . Lambracht-Washington Doris, Rosenberg Roger N. Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology . 2015,第Null期

机译：在一项针对活性DNA A beta 42免疫疗法的小鼠研究中，与TNF受体超家族4/25抗体共同刺激可增强CD4 + CD25 + Foxp3 + T细胞（Tregs）的体内扩增
2. Interaction of TNF with TNF Receptor Type 2 Promotes Expansion and Function of Mouse CD4+CD25+ T Regulatory Cells [J] . Xin Chen, Monika B?umel, Daniela N. M?nnel, The journal of immunology . 2007,第1期

机译：TNF与2型TNF受体的相互作用促进小鼠CD4 + CD25 + T调节细胞的扩增和功能
3. In Situ Manipulation of Tregs Via Combined IL-2 and TNFRSF25 Signaling Pre- and Post-Transplant: A Novel Approach to Regulate GVHD By Marked Expansion of CD4(+)Foxp3(+) T Cells [J] . Wolf Dietlinde, Barreras Henry, Komanduri Krishna V., Biology of blood and marrow transplantation: journal of the American Society for Blood and Marrow Transplantation . 2015,第2Suppla1期

机译：通过结合IL-2和TNFRSF25信号的移植前和移植后Tregs的原位操纵：通过标记的CD4（+）Foxp3（+）T细胞的扩增来调节GVHD的一种新方法。
4. Co-stimulation with TNF receptor superfamily 4/25 antibodies enhances in-vivo expansion of CD4+CD25+Foxp3+ T cells (Tregs) in a mouse study for active DNA Aβ42 immunotherapy [O] . Doris Lambracht-Washington, Roger N. Rosenberg -1

机译：在一项针对活性DNAAβ42免疫疗法的小鼠研究中与TNF受体超家族4/25抗体共同刺激可增强CD4 + CD25 + Foxp3 + T细胞（Tregs）的体内扩增
5. Co-stimulation with TNF receptor superfamily 4/25 antibodies enhances in-vivo expansion of CD4+CD25+Foxp3+ T cells (Tregs) in a mouse study for active DNA Aβ42 immunotherapy [O] . Doris Lambracht-Washington, Roger N. Rosenberg 2015

机译：与TNF受体超家族4/25抗体的共刺激增强了CD4 + CD25 + Foxp3 + T细胞（Tregs）的体内膨胀，在小鼠研究中进行活性DNAAβ42免疫疗法

Co-stimulation with TNF receptor superfamily 4/25 antibodies enhances in-vivo expansion of CD4+CD25+Foxp3+T cells (Tregs) in a mouse study for active DNA A beta 42 immunotherapy

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