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首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Social disruption alters pain and cognition in an animal model of multiple sclerosis
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Social disruption alters pain and cognition in an animal model of multiple sclerosis

机译：社会破坏改变多发性硬化症动物模型中的疼痛和认知

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摘要

Although pain and cognitive deficits are widespread and debilitating symptoms of multiple sclerosis (MS), they remain poorly understood. Theiler's murine encephalomyelitis virus (TMEV) infection is an animal model of MS where disease course is exacerbated by prior stressors. Here chronic infection coupled with prior social stress increased pain behavior and impaired hippocampal-dependent memory consolidation during the demyelinating phase of disease in SJL mice. These results suggest that the TMEV model may be useful in investigating pain and cognitive impairments in MS. However, in contrast to prior Balb/cJ studies, stress failed to consistently alter behavioral and physiological indicators of disease course. (C) 2015 Elsevier B.V. All rights reserved.
机译：尽管疼痛和认知缺陷很普遍，并且使多发性硬化症（MS）的症状虚弱，但对它们的了解仍然很少。泰勒氏鼠脑脊髓炎病毒（TMEV）感染是MS的动物模型，先前的应激源会加剧疾病进程。在SJL小鼠疾病的脱髓鞘阶段，慢性感染加上先前的社会压力增加了疼痛行为并损害了海马依赖性记忆巩固。这些结果表明，TMEV模型可用于研究MS的疼痛和认知障碍。但是，与先前的Balb / cJ研究相反，压力未能持续改变疾病进程的行为和生理指标。 （C）2015 Elsevier B.V.保留所有权利。

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