IL-10 producing B cells partially restore E2-mediated protection against EAE in PD-L1 deficient mice

Zhang Jun; Benedek Gil; Bodhankar Sheetal; Lapato Andrew; Vandenbark Arthur A.; Offner Halina

首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >IL-10 producing B cells partially restore E2-mediated protection against EAE in PD-L1 deficient mice

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IL-10 producing B cells partially restore E2-mediated protection against EAE in PD-L1 deficient mice

机译：产生IL-10的B细胞在PD-L1缺陷小鼠中部分恢复E2介导的针对EAE的保护

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Women with multiple sclerosis (MS) often experience clinical improvement during pregnancy, indicating that sex hormones might have therapeutic effects in MS. Our previous studies have demonstrated that B cells and PD-L1 are crucial for E2 (17 beta-estradiol)-mediated protection against experimental autoimmune encephalomyelitis (EAE). We here demonstrate that the transfer of IL-10(+) B cells into E2-treated PD-L1(-/-) mice after EAE induction could partially restore E2-mediated protection and decrease the frequency of pro-inflammatory cells in the CNS compared to E2/saline treated PD-L1(-/-) mice. Hence, co-administration of IL-10(+) B cells and E2 might have a powerful therapeutic potential for treatment of EAE. (C) 2015 Elsevier B.V. All rights reserved.

机译：多发性硬化症（MS）的妇女通常在怀孕期间经历临床改善，表明性激素可能对MS有治疗作用。我们以前的研究表明，B细胞和PD-L1对于E2（17β-雌二醇）介导的针对实验性自身免疫性脑脊髓炎（EAE）的保护至关重要。我们在这里证明，EAE诱导后，将IL-10（+）B细胞转移到E2处理的PD-L1（-/-）小鼠中可以部分恢复E2介导的保护作用，并降低中枢神经系统促炎细胞的频率与E2 /盐水处理过的PD-L1（-/-）小鼠相比。因此，IL-10（+）B细胞和E2的共同给药可能具有治疗EAE的强大治疗潜力。（C）2015 Elsevier B.V.保留所有权利。

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来源
《Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology》 |2015年第null期|共8页
作者
Zhang Jun; Benedek Gil; Bodhankar Sheetal; Lapato Andrew; Vandenbark Arthur A.; Offner Halina;
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正文语种 eng
中图分类神经病学;
关键词
IL-10; Regulatory B cell; PD-L1; PD-L2; Estrogen; EAE;

机译：IL-10;调节性B细胞;PD-L1;PD-L2;雌激素;EAE;

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1. IL-10 producing B cells partially restore E2-mediated protection against EAE in PD-L1 deficient mice [J] . Zhang Jun, Benedek Gil, Bodhankar Sheetal, Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology . 2015,第Null期

机译：产生IL-10的B细胞在PD-L1缺陷小鼠中部分恢复E2介导的针对EAE的保护
2. Administration of Human Umbilical Cord Blood Cells Produces Interleukin-10 (IL-10) in IL-10 Deficient Mice without Immunosuppression. [J] . McCarthy BA, Reddi AS, Coakley KM, Current stem cell research & therapy . 2010,第1期

机译：人脐带血细胞的管理在没有免疫抑制的IL-10缺陷小鼠中产生白介素10（IL-10）。
3. BIP induces mice CD19(hi) regulatory B cells producing IL-10 and highly expressing PD-L1, FasL [J] . Tang Youfa, Jiang Qing, Ou Yanghui, Molecular Immunology . 2016,第1期

机译：BIP诱导产生IL-10和高表达PD-L1，FasL的小鼠CD19（hi）调节性B细胞
4. Experimental myasthenia gravis in Aire-deficient mice: a link between Aire and regulatory T cells [C] . Revital Aricha, Tali Feferman, Sonia Berrih-Aknin, International Conference on Myasthenia Gravis and Related Disorders . 2012

机译：在Aire缺陷小鼠中的实验性肌肌肌肌瘤：Aire和调节性T细胞之间的联系
5. Lack of APC-derived IL-10 contributes to the pathogenesis of colitis in IL-10 deficient mice. [D] . Albright, Carol. 2003

机译：缺乏APC衍生的IL-10会导致IL-10缺陷小鼠结肠炎的发病。
6. IL-10 producing B cells partially restore E2-mediated protection against EAE in PD-L1 deficient mice [O] . Jun Zhang, Gil Benedek, Sheetal Bodhankar, -1

机译：产生IL-10的B细胞在PD-L1缺陷小鼠中部分恢复E2介导的针对EAE的保护
7. IL-10 producing B cells partially restore E2-mediated protection against EAE in PD-L1 deficient mice [O] . Jun Zhang, Gil Benedek, Sheetal Bodhankar, 2015

机译：IL-10产生B细胞部分恢复E2介导的PD-L1缺陷小鼠中的EAE保护的保护

IL-10 producing B cells partially restore E2-mediated protection against EAE in PD-L1 deficient mice

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