Chronic restraint stress during early Theiler's virus infection exacerbates the subsequent demyelinating disease in SJL mice: II. CNS disease severity.

Young EE; Sieve AN; Vichaya EG; Carcoba LM; Young CR; Ambrus A; Storts R; Welsh CJ; Meagher MW

首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Chronic restraint stress during early Theiler's virus infection exacerbates the subsequent demyelinating disease in SJL mice: II. CNS disease severity.

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Chronic restraint stress during early Theiler's virus infection exacerbates the subsequent demyelinating disease in SJL mice: II. CNS disease severity.

机译：泰勒病毒早期感染期间的慢性束缚应激加剧了SJL小鼠随后的脱髓鞘疾病：II。中枢神经系统疾病的严重程度。

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Theiler's murine encephalomyelitis virus (TMEV) infection is a well-characterized model of multiple sclerosis (MS). Previous research has shown that chronic restraint stress (RS) during early TMEV infection exacerbates behavioral signs of the disease. The present data suggest that RS-induced increases in CNS inflammation, demyelination, and axonal degeneration may underlie this exacerbation. In addition, we report that males exhibit greater CNS inflammation and higher numbers of demyelinating lesions while females show greater susceptibility to RS-induced exacerbation. These findings indicate that RS during early TMEV infection increases CNS lesion formation during the late phase and suggest that the effects of RS are sex-dependent.

机译：泰勒氏鼠脑脊髓炎病毒（TMEV）感染是多发性硬化症（MS）的一个特征鲜明的模型。先前的研究表明，早期TMEV感染期间的慢性束缚应激（RS）加剧了该疾病的行为迹象。目前的数据表明，RS引起的CNS炎症，脱髓鞘和轴突变性的增加可能是这种加重的基础。此外，我们报告男性表现出更大的中枢神经系统炎症和更多的脱髓鞘病变，而女性表现出更大的易感性RS诱发的恶化。这些发现表明，早期TMEV感染期间的RS增加了晚期CNS病变的形成，并表明RS的作用是性别依赖性的。

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《Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology》 |2010年第2期|共11页
作者
Young EE; Sieve AN; Vichaya EG; Carcoba LM; Young CR; Ambrus A; Storts R; Welsh CJ; Meagher MW;
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正文语种 eng
中图分类神经病学与精神病学;医学免疫学;
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1. Chronic restraint stress during early Theiler's virus infection exacerbates the subsequent demyelinating disease in SJL mice: II. CNS disease severity. [J] . Young EE, Sieve AN, Vichaya EG, Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology . 2010,第1a2期

机译：泰勒病毒早期感染期间的慢性束缚应激加剧了SJL小鼠随后的脱髓鞘疾病：II。中枢神经系统疾病的严重程度。
2. Chronic restraint stress during early Theiler's virus infection exacerbates the subsequent demyelinating disease in SJL mice. [J] . Sieve AN, Steelman AJ, Young CR, Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology . 2004,第1a2期

机译：泰勒病毒早期感染期间的慢性束缚应激加剧了SJL小鼠随后的脱髓鞘疾病。
3. Sex-dependent effects of chronic restraint stress during early Theiler's virus infection on the subsequent demyelinating disease in CBA mice. [J] . Sieve AN, Steelman AJ, Young CR, Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology . 2006,第1a2期

机译：早期泰勒病毒感染期间慢性束缚应激对随后CBA小鼠脱髓鞘疾病的性别依赖性影响。
4. Association between Aujeszky's disease virus and/or mycoplasma hyopneumoniae, in exacerbating Actinobacillus pleuropneumoniae infection [C] . F. Diosdado, D. Gonzalez-Vega, Cordoba, Congress of the International Pig Veterinary Society . 1999

机译：Aujeszky疾病病毒和/或支原体蜂鸣器之间的关联，在加剧Actinobacillus胸膜内感染
5. Social stress exacerbations on acute Theiler's virus infection: A role for Interleukin-6. [D] . Johnson, Robin Ranee. 2006

机译：急性泰勒氏病毒感染的社会压力加剧：白介素6的作用。
6. Chronic restraint stress during early Theiler’s virus infection exacerbates the subsequent demyelinating disease in SJL mice: II. CNS disease severity [O] . Erin E. Young, Amy N. Sieve, Elisabeth G. Vichaya, -1

机译：早泰勒氏病毒感染时慢性应激加剧了sJL小鼠随后的脱髓鞘疾病：II。中枢神经系统疾病的严重程度
7. Chronic restraint stress during early Theiler's virus infection exacerbates the subsequent demyelinating disease in SJL mice: II. CNS disease severity [O] . Erin E. Young, Amy N. Sieve, Elisabeth G. Vichaya, 2010

机译：早期患者病毒感染期间的慢性约束应力会加剧SJL小鼠随后的脱髓鞘疾病：II。 CNS病严重程度
8. Effects of Ovine Interferon-Tau Treatment on Theiler's Virus-Induced Demyelination in Female SJL/J Mice [R] . Traweek, K. T. 2001

机译：羊干扰素-Tau治疗对女性sJL / J小鼠甲状腺病毒致脱髓鞘的影响

Chronic restraint stress during early Theiler's virus infection exacerbates the subsequent demyelinating disease in SJL mice: II. CNS disease severity.

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