...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >No evidence of association of the rare nsSNP rs35667974 in IFIH1 with multiple sclerosis.
【24h】

No evidence of association of the rare nsSNP rs35667974 in IFIH1 with multiple sclerosis.

机译：没有证据表明IFIH1中罕见的nsSNP rs35667974与多发性硬化症相关。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Studies suggest that different autoimmune diseases share a common genetic background, in particular, an overlap between Multiple Sclerosis (MS) and type 1 diabetes (T1D) susceptibility loci has been established. A recent study found that four rare SNPs in the IFIH1 (interferon induced with helicase C domain 1) were significantly associated with T1D. To establish if these SNPs were also involved in MS susceptibility, we chose to examine the non-synonymous SNP rs35667974/Ile923Val which displayed the strongest effect in T1D and was also shown to lead to a loss of IFIH1 function in an in vitro study. We have performed the first association study to test if this rare variant is involved in MS susceptibility in a very large sample consisting of 3037 MS patients and 10,657 healthy controls recruited from Italy and the UK. This study has 99% power to demonstrate an association at the 5% level with this rare variant. Our analysis shows that the nsSNP rs35667974/Ile923Val does not have a role in susceptibility to MS.
机译：研究表明，不同的自身免疫性疾病具有共同的遗传背景，特别是多发性硬化症（MS）与1型糖尿病（T1D）易感基因座之间已经建立了重叠。最近的一项研究发现，IFIH1（解旋酶C结构域1诱导的干扰素）中的四个罕见SNP与T1D显着相关。为了确定这些SNP是否也与MS易感性有关，我们选择检查非同义SNP rs35667974 / Ile923Val，它们在T1D中显示出最强的作用，并且在体外研究中还显示导致IFIH1功能丧失。我们已经进行了首次关联研究，以测试这种稀有变体是否与从意大利和英国招募的3037名MS患者和10,657名健康对照组成的大量样本中的MS易感性有关。这项研究具有99％的功效，可以证明与这种罕见变异在5％的水平相关。我们的分析表明，nsSNP rs35667974 / Ile923Val对MS的易感性没有作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号