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首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Clinical and immunological differences between early and late-onset myasthenia gravis in Japan.
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Clinical and immunological differences between early and late-onset myasthenia gravis in Japan.

机译：日本早发和重症肌无力之间的临床和免疫学差异。

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摘要

Immunological characteristics of myasthenia gravis (MG) with late-onset have not been fully elucidated. We examined several autoantibodies and HLA-DRB1 genotyping in 260 Japanese MG patients. Sixty-two MG patients had thymoma. The others were divided into early-onset and late-onset groups separated by an age of 50 years. The ocular form was more frequent in late-onset compared to early-onset group. Seropositivity of anti-muscle-specific tyrosine kinase antibody was 2-3% in acetylcholine receptor-seronegative patients. HLA-DRB1 genotyping failed to detect statistical differences in specific alleles between each group and healthy controls. The immunological profiles in late-onset MG were different from early-onset in Japan.
机译：重症肌无力（MG）的迟发性发作的免疫学特征尚未完全阐明。我们检查了260名日本MG患者的几种自身抗体和HLA-DRB1基因型。 MG患者62例患有胸腺瘤。其他分为早期发作和晚期发作组，年龄分别为50岁。与早发组相比，晚发型眼病的发生率更高。抗肌肉特异性酪氨酸激酶抗体在乙酰胆碱受体血清阴性患者中的血清阳性率为2-3％。 HLA-DRB1基因分型未能检测到各组与健康对照之间特定等位基因的统计差异。迟发性MG的免疫学特征不同于日本的早发性MG。

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