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首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Adjudin attenuates lipopolysaccharide (LPS)- and ischemia-induced microglial activation
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Adjudin attenuates lipopolysaccharide (LPS)- and ischemia-induced microglial activation

机译：adjudin减弱脂多糖（LPS）和局部缺血诱导的小胶质细胞活化

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摘要

Neuroinflammation caused by microglial activation plays a key role in ischemia, neurodegeneration and many other CNS diseases. In this study, we found that Adjudin, a potential non-hormonal male contraceptive, exhibits additional function to reduce the production of proinflammatory mediators. Adjudin significantly inhibited LPS-induced IL-6 release and IL-6, IL-1β, TNF-α expression in BV2 microglial cells. Furthermore, Adjudin exhibited anti-inflammatory properties by suppression of NF-κB p65 nuclear translocation and DNA binding activity as well as ERK MAPK phosphorylation. To determine the in vivo effect of Adjudin, we used a permanent middle cerebral artery occlusion (pMCAO) mouse model and found that Adjudin could reduce ischemia-induced CD11b expression, a marker of microglial activation. Furthermore, Adjudin treatment attenuated brain edema and neurological deficits after ischemia but did not reduce infarct volume. Thus, our data suggest that Adjudin may be useful for mitigating neuroinflammation.
机译：小胶质细胞活化引起的神经炎症在缺血，神经变性和许多其他中枢神经系统疾病中起关键作用。在这项研究中，我们发现潜在的非激素男性避孕药Adjudin表现出减少促炎性介质产生的附加功能。 adjudin显着抑制LPS诱导的BV2小胶质细胞中IL-6的释放以及IL-6，IL-1β，TNF-α的表达。此外，Adjudin通过抑制NF-κBp65核易位和DNA结合活性以及ERK MAPK磷酸化表现出抗炎特性。为了确定Adjudin的体内作用，我们使用了永久性大脑中动脉闭塞（pMCAO）小鼠模型，发现Adjudin可以降低局部缺血诱导的CD11b表达，这是小胶质细胞激活的标志。此外，Adjudin治疗可减轻缺血后的脑水肿和神经功能缺损，但不会减少梗塞面积。因此，我们的数据表明，Adjudin可能对减轻神经炎症有用。

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