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首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Multiple sclerosis-associated retrovirus and related human endogenous retrovirus-W in patients with multiple sclerosis: A literature review
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Multiple sclerosis-associated retrovirus and related human endogenous retrovirus-W in patients with multiple sclerosis: A literature review

机译：多发性硬化症患者的多发性硬化症相关逆转录病毒和相关的人类内源性逆转录病毒-W：文献综述

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摘要

Human endogenous retrovirus-W and the closely related multiple sclerosis-associated retrovirus have been associated with neuro-inflammatory diseases including multiple sclerosis. However, retroviral expression has been reported in brain tissue from healthy subjects as well. In addition, no consensus has been reached on the endogenous/exogenous status of multiple sclerosis-associated retrovirus, which also needs clarification. Therefore, the purpose of this study was to systematically review the published data available on the viruses investigated in patients with multiple sclerosis and to evaluate their hypothesized role as contributing factors to the disease etiology. Evidence suggests that both retroviruses may be endogenous to humans and that failure to suppress viral activity may not be restricted to patients with multiple sclerosis and therefore an unlikely cause of the disease.
机译：人内源性逆转录病毒-W和紧密相关的多发性硬化症相关的逆转录病毒已与包括多发性硬化症在内的神经炎性疾病相关。然而，也已经报道了来自健康受试者的脑组织中的逆转录病毒表达。此外，关于多发性硬化症相关逆转录病毒的内源/外源状态尚未达成共识，这也需要澄清。因此，本研究的目的是系统地回顾已发表的有关多发性硬化症患者所研究病毒的数据，并评估其作为疾病病因的假设作用。有证据表明，两种逆转录病毒都可能是人类内源性的，不能抑制病毒活性可能不限于多发性硬化症患者，因此不太可能是该病的病因。

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