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首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Close association of Guillain-Barre syndrome with antibodies to minor monosialogangliosides GM1b and GM1 alpha.
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Close association of Guillain-Barre syndrome with antibodies to minor monosialogangliosides GM1b and GM1 alpha.

机译：格林-巴利综合征与较小的单唾液酸神经节苷脂GM1b和GM1 alpha抗体密切相关。

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摘要

Cumulative evidence supports the theory that anti-ganglioside antibodies function in the development of Guillain-Barre syndrome (GBS). Some patients have developed GBS after the administration of monosialoganglioside extracted from bovine brain. To clarify the pathogenesis of GBS associated with and without administration of the monosialoganglioside fraction, we investigated serum antibodies to the minor monosialogangliosides GM1b and GM1 alpha in patients with GBS and in control patients. GM1b and GM1 alpha were recognized specifically by the IgG antibody from the GBS patients. Twelve of 20 GBS patients who had high IgG anti-GM1b antibody titers had a preceding gastrointestinal infection. To evaluate the hypothesis that GM1b could be an immunogen, we determined whether a GM1b epitope was present in Campylobacter jejuni isolated from a patient with GBS associated with anti-GM1b antibody. Immunostaining with the monoclonal anti-GM1b antibody indicated that the lipopolysaccharide of the C. jejuni strain has the GM1b epitope. We speculate that an injection of bovine GM1 fraction that contains GM1b, as well as infection by an agent that bears the GM1b epitope, induces production of the anti-GM1b antibody which functions in the development of GBS in some patients.
机译：累积证据支持抗神经节苷脂抗体在格林巴利综合征（GBS）发生中起作用的理论。从牛脑提取的单唾液酸神经节苷脂给药后，一些患者已发展为GBS。为了阐明GBS与单唾液酸神经节苷脂部分给药与否的发病机理，我们研究了GBS患者和对照患者中针对次要单唾液酸神经节苷脂GM1b和GM1α的血清抗体。 GM1b和GM1 alpha被来自GBS患者的IgG抗体特异性识别。 IgG抗GM1b抗体滴度高的20名GBS患者中有12名先前患有胃肠道感染。为了评估GM1b可能是一种免疫原的假说，我们确定了分离自具有抗GM1b抗体的GBS患者的空肠弯曲菌中是否存在GM1b表位。用单克隆抗GM1b抗体进行免疫染色表明空肠弯曲杆菌菌株的脂多糖具有GM1b表位。我们推测注射含有GM1b的牛GM1馏分，以及被带有GM1b表位的药物感染，可诱导产生抗GM1b抗体，该抗体在某些患者中起GBS的作用。

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