• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Chemokines and chemotaxis of leukocytes in infectious meningitis.
【24h】

Chemokines and chemotaxis of leukocytes in infectious meningitis.

机译：感染性脑膜炎的趋化因子和白细胞趋化性。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Chemokines constitute a constantly growing family of small inflammatory cytokines. They have been implied in many different diseases of the CNS including trauma, stroke and inflammation, e.g., multiple sclerosis. In this review we focus on the role of chemokines in infectious meningitis of bacterial or viral origin. In experimental bacterial meningitis induced by Listeria monocytogeneses both CXC and CC chemokines namely MIP-1alpha, MIP-1beta and MIP-2 are produced intrathecally by meningeal macrophages and leukocytes which infiltrate into the CNS. In patients with bacterial meningitis, IL-8, GROalpha, MCP-1, MIP-1alpha and MIP-1beta are detectable in the CSF. These chemokines contribute to CSF mediated chemotaxis on neutrophils and PBMC in vitro. In viral meningitis IL-8, IP-10 and MCP-1 are identified in the CSF to be responsible for chemotactic activity on neutrophils, PBMC and activated T cells. Taken collectively these data indicate that the recruitment of leukocytes in infectious meningitis involves the intrathecal production of chemokines.
机译：趋化因子构成了不断增长的小炎症细胞因子家族。它们被暗示存在于CNS的许多不同疾病中，包括创伤，中风和炎症，例如多发性硬化。在这篇综述中，我们着眼于趋化因子在细菌性或病毒性感染性脑膜炎中的作用。在由单核细胞增生性李斯特菌诱导的实验性细菌性脑膜炎中，CXC和CC趋化因子即MIP-1alpha，MIP-1beta和MIP-2均通过浸入CNS的脑膜巨噬细胞和白细胞在鞘内产生。在细菌性脑膜炎患者中，在脑脊液中可检测到IL-8，GROalpha，MCP-1，MIP-1alpha和MIP-1beta。这些趋化因子在体外有助于中性粒细胞和PBMC对CSF介导的趋化作用。在病毒性脑膜炎中，在脑脊液中发现IL-8，IP-10和MCP-1负责中性粒细胞，PBMC和活化T细胞的趋化活性。归纳起来，这些数据表明在传染性脑膜炎中白细胞的募集涉及鞘内趋化因子的产生。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号