Cytotoxic phloroglucinols from the leaves of Myrtus communis.

Cottiglia F.; Casu L.; Leonti M.; Caboni P.; Floris C.; Busonera B.; Farci P.; Ouhtit A.; Sanna G.

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Cytotoxic phloroglucinols from the leaves of Myrtus communis.

机译：产自Myrtus communis 叶片的细胞毒性间苯三酚。

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Bioactivity-guided fractionation of a dichloromethane extract of the leaves of Myrtus communis led to the isolation of phloroglucinol derivatives. The structures of the new myrtucommulones J, K, and L (1-3) and the previously known myrtucommulone A (4) were elucidated on the basis of extensive 1D and 2D NMR experiments as well as high-resolution mass spectrometry. Myrtucommulone J was obtained as a tautomeric pair (1/1a). The compounds were tested in vitro for their cytotoxic and antibacterial activities.

机译：生物活性指导下的山茱M叶片二氯甲烷提取物的分离导致间苯三酚衍生物的分离。在广泛的1D和2D NMR实验以及高分辨率质谱的基础上，阐明了新的Myrtucommulones J，K和L（1-3）和先前已知的Myrtucommulone A（4）的结构。获得了互变异构对（1 / 1a）的肉豆蔻酮J。体外测试了这些化合物的细胞毒性和抗菌活性。

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来源
《Journal of natural products》 |2012年第2期|共5页
作者
Cottiglia F.; Casu L.; Leonti M.; Caboni P.; Floris C.; Busonera B.; Farci P.; Ouhtit A.; Sanna G.;
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正文语种 eng
中图分类生药学（天然药物学）;
关键词
antibacterial properties; chemical composition; chemical structure; cytotoxic compounds; cytotoxicity; leaves; medicinal plants; neoplasms; pathogens; phloroglucinol; plant composition; Myrtus communis; Myrtus; Myrtaceae; Myrtales; dicotyledons; angiosperms; Spermatophyta; plants; eukaryotes; bactericidal properties; cancers; chemical constituents of plants; drug plants; medicinal herbs; officinal plants;

机译：抗菌特性;化学成分;化学结构;细胞毒性化合物;细胞毒性;叶;药用植物;新生物;病原体;间苯三酚;植物组成;沙蚕;沙丁鱼;桃金娘科;植物;真核生物;细菌癌症;植物的化学成分;药用植物;药草;药用植物;

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4. Cytotoxic phloroglucinols from the leaves of Myrtus communis. [J] . Cottiglia F., Casu L., Leonti M., Journal of natural products . 2012,第2期

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Cytotoxic phloroglucinols from the leaves of Myrtus communis.

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