...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of natural products >Trichormamides A and B with Antiproliferative Activity from the Cultured Freshwater Cyanobacterium Trichormus sp UIC 10339
【24h】

Trichormamides A and B with Antiproliferative Activity from the Cultured Freshwater Cyanobacterium Trichormus sp UIC 10339

机译：从培养的淡水蓝藻Trichormus sp UIC 10339具有抗增殖活性的三酰胺A和B

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Two new cyclic lipopeptides, trichormamides A (1) and B (2), were isolated from the cultured freshwater cyanobacterium Trichormus sp. UIC 10339. The strain was obtained from a sample collected in Raven Lake in Northern Wisconsin. The planar structures of trichormamides A (1) and B (2) were determined using a combination of spectroscopic analyses including HRESIMS and 1D and 2D NMR experiments. The absolute configurations of the amino acid residues were assigned by the advanced Marfey's method after acid hydrolysis. Trichormamide A (1) is a cyclic undecapeptide containing two D-amino acid residues (D-Tyr and D-Leu) and one beta-amino acid residue (beta-aminodecanoic acid). Trichormamide B (2) is a cyclic dodecapeptide characterized by the presence of four nonstandard alpha-amino acid residues (homoserine, N-methylisoleucine, and two 3-hydroxyleucines) and one beta-amino acid residue (beta-aminodecanoic acid). Trichormamide B (2) was cytotoxic against MDA-MB-435 and HT-29 cancer cell lines with IC50 values of 0.8 and 1.5 mu M, respectively.
机译：从培养的淡水蓝藻Trichormus sp。中分离出两个新的环状脂肽三氯酰胺A（1）和B（2）。 UIC 10339.该菌株是从在威斯康星州北部的Raven Lake收集的样品中获得的。使用包括HRESIMS在内的光谱分析以及1D和2D NMR实验的组合，确定了三氯酰胺A（1）和B（2）的平面结构。氨基酸残基的绝对构型是在酸水解后通过先进的Marfey法确定的。 Trichormamide A（1）是一种环状十一肽，包含两个D-氨基酸残基（D-Tyr和D-Leu）和一个β-氨基酸残基（β-氨基癸酸）。 Trichormamide B（2）是一种环状十二肽，其特征是存在四个非标准α-氨基酸残基（高丝氨酸，N-甲基异亮氨酸和两个3-羟基亮氨酸）和一个β-氨基酸残基（β-氨基癸酸）。 Trichormamide B（2）对MDA-MB-435和HT-29癌细胞系具有细胞毒性，IC50值分别为0.8和1.5μM。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号