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首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Gastroretentive microparticles for drug delivery applications
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Gastroretentive microparticles for drug delivery applications

机译：用于药物输送的胃滞留微粒

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摘要

Many strategies have been proposed to explore the possibility of exploiting gastroretention for drug delivery. Such systems would be useful for local delivery, for drugs that are poorly soluble at higher pH or primarily absorbed from the proximal small intestine. Generally, the requirements of such strategies are that the vehicle maintains controlled drug release and exhibits prolonged residence time in the stomach. Despite widespread reporting of technologies, many have an inherent drawback of variability in transit times. Microparticulate systems, capable of distributing widely through the gastrointestinal tract, can potentially minimise this variation. While being retained in the stomach, the drug content is released slowly at a desired rate, resulting in reduced fluctuations in drug levels. This review summarises the promising role of microencapsulation in this field, exploring both floating and mucoadhesive microparticles and their application in the treatment of Helicobacter pylori, highlighting the clinical potential of eradication of this widespread infection.
机译：已经提出了许多策略来探索利用胃滞留进行药物递送的可能性。这样的系统对于局部递送，对于在较高pH下难溶或主要从近端小肠吸收的药物将是有用的。通常，这种策略的要求是媒介物保持受控的药物释放并在胃中显示出延长的停留时间。尽管已经广泛报道了技术，但是许多技术具有运输时间可变性的固有缺陷。能够通过胃肠道广泛分布的微粒系统可以潜在地最小化这种变化。在保留在胃中的同时，药物含量以所需的速率缓慢释放，从而降低了药物水平的波动。这篇综述总结了微囊化在该领域中的有希望的作用，探索了漂浮的和粘膜粘附的微粒以及它们在幽门螺杆菌治疗中的应用，突出了根除这种广泛感染的临床潜力。

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