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首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Bioadhesive properties of poly(anhydride) nanoparticles coated with different molecular weights chitosan
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Bioadhesive properties of poly(anhydride) nanoparticles coated with different molecular weights chitosan

机译：分子量不同的壳聚糖包覆的聚（酸酐）纳米颗粒的生物粘附性能

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摘要

The aim of this study was to develop and characterize the bioadhesive properties of poly(anhydride) nanoparticles coated with two types of low-molecular weight chitosan (CH20 of 20kDa or CH50 of 50kDa) or their thiolated conjugates. Nanoparticles were prepared by a solvent displacement method and characterized by measuring the size, zeta potential, morphology and composition. For bioadhesion studies, nanoparticles were fluorescently labelled with rhodamine B isothiocyanate. In all cases, coated nanoparticles showed a slightly higher size and lower negative zeta potential than uncoated nanoparticles. Nanoparticles coated with CH20 showed a higher adhesive capacity than uncoated nanoparticles. On the contrary, when nanoparticles were coated with CH50, the resulting carriers displayed a decreased ability to develop adhesive interactions within the gut. Finally, the coating of nanoparticles with thiolated chitosan improved their adhesive abilities. Poly(anhydride) nanoparticles coated with thiolated chitosan can be considered as promising bioadhesive particulate carriers for oral delivery strategies.
机译：这项研究的目的是开发和表征涂有两种低分子量壳聚糖（CH20为20kDa或CH50为50kDa）或其硫醇化缀合物的聚（酸酐）纳米颗粒的生物粘附特性。通过溶剂置换法制备纳米颗粒，并通过测量尺寸，ζ电势，形态和组成对其进行表征。为了进行生物粘附性研究，纳米粒子用若丹明B异硫氰酸酯进行了荧光标记。在所有情况下，与未涂覆的纳米颗粒相比，涂覆的纳米颗粒显示出略高的尺寸和更低的负ζ电势。涂覆有CH20的纳米颗粒比未涂覆的纳米颗粒具有更高的粘合能力。相反，当纳米颗粒用CH50包被时，所得的载体表现出降低的在肠道内形成胶粘剂相互作用的能力。最后，用硫醇化壳聚糖涂覆纳米颗粒改善了它们的粘合能力。涂有硫醇化壳聚糖的聚（酸酐）纳米颗粒可以被认为是用于口服递送策略的有前途的生物粘附颗粒载体。

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