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首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >A 'drug cocktail' delivered by microspheres for the local treatment of rat glioblastoma
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A 'drug cocktail' delivered by microspheres for the local treatment of rat glioblastoma

机译：微球递送的“药物鸡尾酒”，用于局部治疗大鼠胶质母细胞瘤

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摘要

For the treatment of glioblastoma multiforme, an "anticancer drug cocktail" delivered by biodegradable poly-lactide-co-glycolide (PLGA)-microspheres is proposed. Celecoxib, etoposide, and elacridar were encapsulated by an oil/water emulsification solvent evaporation method. Drug-loaded microspheres were analyzed for their physicochemical properties and evaluated in a rat glioblastoma model. Microspheres had a mean diameter 10-20 urn, and encapsulation rates varied upon lipophilicity of the drug (celecoxib: 97.4 ±0.4%; elacridar: 98.1 ±0.3%; and etoposide: 38.7 ±8.3%). Drug release of celecoxib and elacridar resulted in a burst (t50: 3.1 h and 1.0 h, respectively) while etoposide release was slower (t50:45.3 h). The comparison of celecoxib (p = 0.021) and etoposide microspheres (p = 0.002) as well as their combination (p = 0.011) led to a significant increase in the probability of survival compared to blank microspheres. Local delivery of celecoxib and etoposide microspheres was found to be suitable for the treatment of glioblastoma in rats although simultaneous drug administration did not improve the therapeutic outcome.
机译：为了治疗多形性胶质母细胞瘤，提出了由可生物降解的聚丙交酯-共-乙交酯（PLGA）-微球递送的“抗癌药混合物”。通过油/水乳化溶剂蒸发法将塞来昔布，依托泊苷和依拉克达包封。分析了载药微球的理化性质，并在大鼠胶质母细胞瘤模型中进行了评估。微球的平均直径为10-20微米，并且包封率随药物的亲脂性而变化（塞来昔布：97.4±0.4％;依拉西达：98.1±0.3％;依托泊苷：38.7±8.3％）。塞来昔布和依拉西达的药物释放导致爆发（分别为t50：3.1 h和1.0 h），而依托泊苷的释放较慢（t50：45.3 h）。与空白微球相比，塞来昔布（p = 0.021）和依托泊苷微球（p = 0.002）以及它们的组合（p = 0.011）的比较导致存活率显着提高。塞来昔布和依托泊苷微球的局部递送被发现适合于大鼠胶质母细胞瘤的治疗，尽管同时给药并不能改善治疗效果。

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