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首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Synthesis and characterisation of alginate/chitosan nanoparticles as tamoxifen controlled delivery systems
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Synthesis and characterisation of alginate/chitosan nanoparticles as tamoxifen controlled delivery systems

机译：海藻酸盐/壳聚糖纳米粒的合成和表征为他莫昔芬控制的递送系统

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摘要

Polysaccharides have shown ideal features for their application in nanomedicine as nanoparticulated systems. Nanoparticles based on mixtures of alginate and chitosan (A/Q-50/50, formed by 50% alginate and 50% chitosan, and A/Q-70/30, formed by 70% alginate and 30% alginate) have been synthesised by an emulsification method and stabilised by amide bond formation. Tamoxifen (TMX) was loaded into these systems, and they were assayed as controlled delivery formulations. Results showed the formation of spherical nanoparticles with very small size (19-28 nm). The presence of amide bonds was determined by FT-IR and confirmed by Thermogravimetric analysis studies. TMX incorporation was achieved successfully (2-3 μg TMX per mg NP), and maximum TMX release took place between 8 and 24 h. This study shows that interaction between TMX and the system was dependent on nanoparticle composition, being the composition with higher proportion of alginate the one which showed the best release control of the drug.
机译：多糖已显示出其作为纳米颗粒系统应用于纳米医学的理想特征。通过藻酸盐和壳聚糖的混合物（由50％藻酸盐和50％壳聚糖形成的A / Q-50 / 50，和由70％藻酸盐和30％海藻酸盐形成的A / Q-70 / 30）合成了纳米粒子。一种乳化方法，并通过酰胺键的形成得以稳定。将他莫昔芬（TMX）加载到这些系统中，并将它们作为受控传递制剂进行分析。结果显示形成了非常小的尺寸（19-28 nm）的球形纳米颗粒。通过FT-IR确定酰胺键的存在，并通过热重分析研究证实。成功实现了TMX的掺入（每毫克NP含2-3μgTMX），并且最大的TMX释放发生在8到24小时之间。这项研究表明，TMX与系统之间的相互作用取决于纳米颗粒的组成，因为藻酸盐的组成比例较高，而后者显示出最佳的药物释放控制。

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