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首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Surfactant-free poly(lactide-co-glycolide) nanoparticles for improving in vitro anticancer efficacy of tetrandrine
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Surfactant-free poly(lactide-co-glycolide) nanoparticles for improving in vitro anticancer efficacy of tetrandrine

机译：不含表面活性剂的聚丙交酯-乙交酯共聚物纳米粉，用于改善粉防己碱的体外抗癌功效

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摘要

The objective of this study was to improve the efficacy of a natural compound tetrandrine against cancer by designing surfactant-free poly(lactic-co-glycolic acid) (PLGA) nanoparticles as drug carriers for tetrandrine. Nanoparticles were prepared from PLGA via the nano-precipitation method with or without the presence of surfactant poly(vinyl alcohol) (PVA) to encapsulate tetrandrine. Tetrandrine-loaded surfactant-free PLGA nanoparticles had an average particle size of 169.3nm and morphology similar to the PLGA nanoparticles prepared using PVA as the surfactant. Tetrandrine-loaded surfactant-free PLGA nanoparticles could retard drug release in phosphate buffered saline (PBS) at pH 7.4 and the cumulative release of tetrandrine reached up to 68.33% over a period of 120h. A549 cell line was used as the model cancer cells to investigate anticancer capability of tetrandrine-loaded surfactant-free PLGA nanoparticles via apoptosis assay, cytotoxicity and lysosome injury studies. The results showed that tetrandrine-loaded surfactant-free PLGA nanoparticles could effectively reduce cell viability and synergistically enhance tetrandrine-induced cell apoptosis.
机译：这项研究的目的是通过设计无表面活性剂的聚乳酸-乙醇酸共聚物（PLGA）纳米颗粒作为粉防己碱的药物载体，提高天然化合物粉防己碱对癌症的疗效。在存在或不存在表面活性剂聚（乙烯醇）（PVA）的情况下，通过纳米沉淀法从PLGA制备纳米颗粒以包裹粉防己碱。负载有粉防己碱的不含表面活性剂的PLGA纳米颗粒的平均粒径为169.3nm，其形态与使用PVA作为表面活性剂制备的PLGA纳米颗粒相似。载有粉防己碱的不含表面活性剂的PLGA纳米粒子可以在pH 7.4的磷酸盐缓冲盐水（PBS）中延迟药物释放，粉防己碱的累积释放在120h内高达68.33％。 A549细胞系被用作模型癌细胞，通过凋亡分析，细胞毒性和溶酶体损伤研究来研究载有粉防己碱的不含表面活性剂的PLGA纳米颗粒的抗癌能力。结果表明，载有粉防己碱的不含表面活性剂的PLGA纳米颗粒可有效降低细胞活力，并协同增强粉防己碱诱导的细胞凋亡。

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