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首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Opioid-based micro and nanoparticulate formulations: alternative approach on pain management
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Opioid-based micro and nanoparticulate formulations: alternative approach on pain management

机译：基于阿片类药物的微米和纳米颗粒制剂：疼痛治疗的替代方法

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Context Opioids have been used as the reference treatment on chronic pain. However, they are related to serious adverse effects which affect the patient compliance to treatment, as well as, his quality of life. Particulate formulations have been investigated as an alternative to improve opioid efficacy and safety. Objective Summarise the available studies concerning micro and nanoencapsulated opioid formulations discussing their biopharmaceutical characteristics, such as composition, size, in vitro release, pharmacokinetic and antinociceptive profile. Methods Papers available in 1995-2015 at Medline, Science Direct and Web of Science databases were collected and assessed. Searches were performed using varied combinations of the keywords of this work. Results Opioid-loaded particles showed prolonged drug release with maintenance of serum therapeutic concentrations and extended analgesia when compared with the free drugs. The side effects incidences were reduced or maintained the same. Conclusion Particulate formulations can significantly increase both potency and safety profiles of opioids.
机译：背景阿片类药物已被用作慢性疼痛的参考治疗方法。但是，它们与严重的副作用有关，这些副作用影响患者对治疗的依从性以及他的生活质量。已经研究了颗粒制剂作为改善阿片样物质功效和安全性的替代方法。目的总结关于微胶囊和纳米胶囊的阿片类药物制剂的现有研究，讨论其生物药物特性，例如组成，大小，体外释放，药代动力学和抗伤害感受。方法收集并评估1995-2015年在Medline，Science Direct和Web of Science数据库中可获得的论文。使用该工作的关键字的各种组合进行搜索。结果与游离药物相比，载有阿片样物质的颗粒显示出延长的药物释放，同时维持血清治疗浓度并延长了镇痛作用。副作用发生率降低或保持不变。结论颗粒剂可以显着提高阿片类药物的效力和安全性。

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