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首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Role of solventon-solvent ratio on microsphere formation using the solvent removal method
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Role of solventon-solvent ratio on microsphere formation using the solvent removal method

机译：溶剂/非溶剂比例对使用溶剂去除法形成微球的作用

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摘要

The importance of good solvent concentration in the non-solvent mixture and the non-solvent viscosity on the ahility to form microspheres using solvent removal process was investigated.The higher the viscosity of the polymer solutions,the higher the concentration of good solvent needed in the non-solvent mixture to produce microspheres.This finding was clue to faster precipitation of the polymer phase.Also,the addition of a model drug,fluorescein isothiocyanate conjugated-labelled bovine serum albumin,to the polymer solution (10% poly-L-lactic acid:poly(fumaric-co-sebacic) anhydride in methylene chloride) resulted in an overall lower polymer solution viscosity (15.5cP with fluorescein isothiocyanate conjugated-labelled box ine scrum albumin as compared with 18.25 cP for blank polymer at 25 deg C).Additionally,the effect of good solvent concentration on non-solvent viscosity was evaluated,and the viscosity decreased as the concentration of good solvent increased.The effect of good solvent concentration on the non-solvent mixture on sphere formation was of great importance.Microspheres would not form when the good polymer solvent (methylene chloride) in the non-solvent phase was too low (below 175ml for poly-L-lactic acid or 150ml for poly(D,L-lacticl-co-glycolid)) or was replaced by another good solvent such as ethyl acetate,even though the same viscosity was achieved.It was shown that the concentration of the good solvent in the non-solvent mixture was more of a controlling factor than the viscosity of the non-solvent mixture in microsphere formation and the findings support the conclusion that diffusion is the main controlling parameter in solvent removal.
机译：研究了非溶剂混合物中良好溶剂浓度的重要性以及非溶剂粘度对使用溶剂去除工艺形成微球的能力的影响。聚合物溶液的粘度越高，在溶剂中所需的良好溶剂的浓度就越高。非溶剂混合物产生微球。这一发现是聚合物相更快沉淀的线索。此外，向聚合物溶液中添加了模型药物异硫氰酸荧光素共轭标记的牛血清白蛋白（10％聚-L-乳酸酸：聚（富马酸-癸二酸）酐在二氯甲烷中的溶液）总体上降低了聚合物溶液的粘度（用异硫氰酸荧光素共轭标记的盒式Scrum白蛋白为15.5cP，而空白聚合物在25℃时为18.25cP）。此外，评估了良好溶剂浓度对非溶剂粘度的影响，并且随着良好溶剂浓度的增加，粘度降低了。非溶剂混合物中的nt浓度对形成球非常重要。当非溶剂相中的良聚合物溶剂（二氯甲烷）太低时（聚L-乳酸低于175ml或150ml低于150ml），则不会形成微球对于聚（D，L-乳酸-共-糖基））或已被另一种良好的溶剂（如乙酸乙酯）代替，即使获得了相同的粘度。也表明在非溶剂混合物中良好溶剂的浓度在微球形成过程中，比非溶剂混合物的粘度更重要的是控制因素，这些发现支持以下结论：扩散是溶剂去除的主要控制参数。

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