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首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Preparation and evaluation of microcapsules using polymerized rosin as a novel wall forming material
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Preparation and evaluation of microcapsules using polymerized rosin as a novel wall forming material

机译：聚合松香作为新型成壁材料的微囊制备与评价

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Sustained release diclofenac sodium microcapsules were prepared using polymerized rosin as a novel wall-forming material by a solvent evaporation technique.A novel method developed in our laboratory with the potential for scale-up and production of polymerized rosin microcapsules is detailed.These microcapsules might have application for development of implant/depot systems,primarily due to a sustained/controlled release capability and potential biocompatibility of polymerized rosin.The effect of variables like solvent systems,stirring speed and temperature were previously optimized.The solution system of drug and polymerized rosin dissolved in iso-propyl alcohol and acetone is sprayed with the help of a 0.5mm nozzle spray gun in liquid paraffin maintained at 60 C in the stirring condition.Varying drug:polymer ratios,namely 1:1,1:2,2:1,1:3 and 3:1,were employed for microcapsule preparation.The prepared microcapsules were evaluated for size,shape,drug content and in vitro drug release.The morphology of microcapsules was characterized by scanning electron microscopy.The microcapsules show sustained release curves at pH 7.4 phosphate buffer for up to 10 h.The data obtained from the dissolution profiles were compared in the light of different kinetics models and the regression coefficients were compared.The in vitro dissolution study confirmed the Higuchi-order release pattern.Particle size and release data analysis from five consecutive batches prepared in the laboratory indicated suitable reproducibility of the proposed solvent evaporation process.
机译：以聚合松香为新型成壁材料，采用溶剂蒸发技术制备了缓释双氯芬酸钠微胶囊，详细介绍了本实验室开发的具有规模化生产聚合松香微胶囊的潜力的新型方法。应用在开发植入/储库系统中，主要是由于聚合松香的缓释/控释能力和潜在的生物相容性。之前优化了溶剂系统，搅拌速度和温度等变量的影响。药物和聚合松香的溶液系统溶解在搅拌条件下，在保持在60℃的液态石蜡中，借助0.5mm喷嘴的喷枪在异丙醇和丙酮中喷洒在不同浓度的药物：聚合物比，即1：1,1：2,2：1，采用1：3和3：1制备微胶囊。对制备的微胶囊的大小，形状，药物含量和体外药物释放进行评估。通过扫描电子显微镜对微胶囊的形态进行表征。微胶囊在pH 7.4磷酸盐缓冲液中长达10 h表现出持续释放曲线，根据不同的动力学模型比较了溶出曲线的数据并比较了回归系数体外溶出研究证实了Higuchi有序释放模式。在实验室连续制备的5个批次中，颗粒大小和释放数据分析表明，所提出的溶剂蒸发过程具有适当的重现性。

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