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首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Preparation of sodium fluoride-loaded gelatin microspheres characterization and cariostatic studies
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Preparation of sodium fluoride-loaded gelatin microspheres characterization and cariostatic studies

机译：载有氟化钠的明胶微球的制备及抑癌研究

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摘要

Sodium fluoride-loaded gelatin microspheres(NaF-GMS)were prepared using double-phase emulsified condensation polymerization.The average diameter of microspheres was(11.33(+-)5.56)mu m.The drug content and encapsulation efficiency were 8.80% and 76.73%,respectively.The fluoride releasing profiles of NaF-GMS in physiological saline and artificial saliva(pH 4.5,pH 6.8)showed that NaF-GMS had a sustained-release property and fluoride release rate was increased in pH 4.5 artificial saliva.Experiments conducted in rabbits' oral cavity using NaF-GMS and NaF solution as control revealed NaF-GMS could maintain oral fluoride retention longer than NaF solution.Cariostatie abilities of NaF-GMS including demineralization prohibition in vitro,fluoride deposition in artificial dental plaque and the ability of targeting to cariogenic bacteria were investigated in artificial dental plaque.The results indicated NaF-GMS with lower fluoride concentrations could achieve equivalent cariostatic effect to the concentrated NaF solution,at the same time,could prolong fluoride retention in dental plaque.Microscopic observation showed that NaF-GMS carrying fusion protein of glucan-binding domain could adhere more bacteria than NaF-GMS and this might indicate the possibility of targeting to cariogenic bacteria when NaF-GMS were properly modified.
机译：采用双相乳化缩聚法制备了载有氟化钠的明胶微球（NaF-GMS），微球的平均直径为（11.33（±）5.56）μm，药物含量和包封率分别为8.80％和76.73％。 NaF-GMS在生理盐水和人工唾液（pH 4.5，pH 6.8）中的氟释放曲线表明，NaF-GMS具有缓释特性，在pH 4.5人工唾液中氟化物释放速率增加。 NaF-GMS和NaF溶液作为对照的家兔口腔显示NaF-GMS比NaF溶液可以保持更长的口服氟保留时间。NaF-GMS的定律能力包括体外脱矿质，人造牙菌斑中的氟化物沉积和靶向能力在人造牙菌斑中对致龋菌进行了研究。结果表明，氟化物浓度较低的NaF-GMS可以达到与龋齿等效的抗癌作用。显微镜观察显示，带有葡聚糖结合域融合蛋白的NaF-GMS可以比NaF-GMS粘附更多的细菌，这可能表明有可能靶向致龋NaF-GMS正确修饰后细菌。

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