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首页> 外文期刊>Journal of nephrology. >Pathogenesis of Takayasu's arteritis.
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Pathogenesis of Takayasu's arteritis.

机译：高津市大动脉炎的发病机制。

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Takayasu's arteritis is an inflammatory disease of the arteries that involves large vessels. The inflammatory lesions in Takayasu's arteritis originate in the vasa vasorum and are followed by cellular infiltration, mainly composed of T cells (gammadelta lymphocytes, cytotoxic T lymphocytes, T helper cells), but also of natural killer cells, dendritic cells, monocytes and granulocytes, invading the outer layer of the media and/or its neighbouring adventitia. At this stage, positive production of inflammatory cytokines and/or adhesion molecules around these areas is remarkable. According to data available--in Takayasu's arteritis--interleukin-6, interleukin-1 and RANTES are released in large amounts by infiltrating inflammatory cells within damaged tissue, as well as by circulating inflammatory cells, and very likely help maintain the aberrant immune activation, by promoting endothelial cells activation and by inducing lymphocyte infiltration. Although the nature of the antigen that triggers the auto-immune process is still unknown, the infiltrating T lymphocytes may recognize one or a few self-antigens processed and presented in association with HLA. A considerable percentage of patients with Takayasu's arteritis have immune complexes in sera; moreover, on peripheral blood lymphocyte, Fc receptors and antibodies reactive against human endothelial cells (AECA) have been detected. This observation raised the possibility that AECA might have a role in endothelial cell activation and expression of adhesion molecules, which will facilitate leukocyte traffic.
机译：Takayasu的动脉炎是一种涉及大血管的炎性疾病。 Takayasu动脉炎的炎性病变起源于血管脉管，随后是细胞浸润，主要由T细胞（γ淋巴细胞，细胞毒性T淋巴细胞，T辅助细胞）组成，但也包括自然杀伤细胞，树突状细胞，单核细胞和粒细胞，侵入培养基的外层和/或其邻近的外膜。在这个阶段，在这些区域周围的炎症细胞因子和/或粘附分子的阳性产生是显着的。根据可获得的数据-在高津市的动脉炎中-白细胞介素6，白细胞介素1和RANTES通过浸润受损组织内的炎性细胞以及循环炎性细胞而大量释放，并且很可能有助于维持异常的免疫激活通过促进内皮细胞活化和诱导淋巴细胞浸润。尽管触发自身免疫过程的抗原的性质仍然未知，但浸润的T淋巴细胞可能会识别一种或几种与H​​LA结合处理和呈递的自身抗原。 Takayasu的动脉炎患者中有相当大的比例具有血清中的免疫复合物。此外，在外周血淋巴细胞上，已检测出对人内皮细胞（AECA）具有反应性的Fc受体和抗体。该观察结果提出了AECA可能在内皮细胞活化和粘附分子表达中起作用的可能性，这将促进白细胞运输。

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