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首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Scintigraphic imaging of infections with 99m-Tc-labelled glutathione liposomes
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Scintigraphic imaging of infections with 99m-Tc-labelled glutathione liposomes

机译:99m-Tc标记的谷胱甘肽脂质体感染的闪烁成像

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In this study,liposomes containing glutathione were evaluated to detect infection in mice. Glutathione liposomes were labelled by suing 99m Tclabelled-HMPAO (hexamethyl propylamine oxime). Mice were infected in the thigh by intramuscular injection with turbentine. Labelled liposomes were applied to the tail vein of the mice intravenously. At fixed time intervals they were sacrificed. The animals were imaged under a gamma camera. Then, tissue samples were excised and radioactivity of all orgas was counted. bscess-to-muscle, abscess-to-liver, and abscess-to-speleen ratios were calculated. The ratios of abscess-to-muscle were found to be 1.6 and 11.6 at 1 h and 24 h, respectively. According to these data, the abscess can be defined at 1h and it became more clear with time.
机译:在这项研究中,评估了含有谷胱甘肽的脂质体以检测小鼠中的感染。通过起诉99m Tclabelled-HMPAO(六甲基丙胺肟)标记谷胱甘肽脂质体。肌内注射Turbentine感染大腿上的小鼠。将标记的脂质体静脉内应用于小鼠的尾静脉。在固定的时间间隔处死他们。在伽马相机下对动物成像。然后,切下组织样品并计数所有高潮的放射性。计算脓肿与肌肉,脓肿与肝脏的比率以及脓肿与硬骨的比率。发现脓肿与肌肉的比率在1 h和24 h分别为1.6和11.6。根据这些数据,脓肿可以在1h定义,并且随着时间的推移变得更加清晰。

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