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首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Effects of an oral insulin nanoparticle administration on hepatic glucose metabolism assessed by ~(13)C and ~2H isotopomer analysis
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Effects of an oral insulin nanoparticle administration on hepatic glucose metabolism assessed by ~(13)C and ~2H isotopomer analysis

机译：通过〜（13）C和〜2H同位素分析评估口服胰岛素纳米颗粒对肝脏葡萄糖代谢的影响

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摘要

The purpose of this study was to evaluate hepatic glucose metabolism of diabetic induced rats after a daily oral load of insulin nanoparticles over 2 weeks. After the 2-week treatment, an oral glucose tolerance test was performed with [U-~(13)C] glucose and ~2H2O. Plasma glucose ~2H and ~(13)C enrichments were quantified and the contribution of glycogenosis and gluconeogenesis to overall glucose production were estimated. Animals with the insulin nanoparticles displayed the lowest glycemia before the oral glucose tolerance test. In all animals, 75% of the total glucose production was from gluconeogenesis and glycogen synthesis was only detected in some animals. Gluconeogenic pathway was an active contributor to hepatic glucose production and the treatment with oral delivered insulin nanoparticles did not alter this contribution, suggesting that under this treatment, protocol hepatic glucose metabolism is not the most relevant target of insulin action but instead a more generalised effect in peripheral tissues.
机译：这项研究的目的是评估每日口服胰岛素纳米颗粒超过2周后，糖尿病诱导大鼠的肝糖代谢。治疗2周后，用[U-〜（13）C]葡萄糖和〜2H2O进行口服葡萄糖耐量试验。量化血浆葡萄糖〜2H和〜（13）C富集，并评估糖原异生和糖异生对总葡萄糖产生的贡献。具有胰岛素纳米颗粒的动物在口服葡萄糖耐量试验之前显示出最低的血糖水平。在所有动物中，总葡萄糖产量的75％来自糖异生，仅在某些动物中检测到糖原合成。糖原生成途径是肝葡萄糖产生的积极贡献者，口服递送的胰岛素纳米颗粒治疗并没有改变这种贡献，这表明在这种治疗下，方案肝葡萄糖代谢不是胰岛素作用的最相关目标，而是更普遍的作用。周围组织。

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