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首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Effect of microencapsulation of Lactobacillus salivarus 29 into alginate/chitosan/alginate microcapsules on viability and cytokine induction
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Effect of microencapsulation of Lactobacillus salivarus 29 into alginate/chitosan/alginate microcapsules on viability and cytokine induction

机译：唾液乳杆菌29微囊化成藻酸盐/壳聚糖/藻酸盐微胶囊对存活率和细胞因子诱导的影响

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Harsh gastric condition causes low bioavailability of probiotics when supplied orally. Polymeric encapsulation has successfully protected bacteria from harsh gastric condition and ultimately increased persistency and multiplication at the targeted region. In this study, we encapsulated LS29 into ACA microcapsules and characterized them. The survivability and release of LS29 from LS29-loaded ACA microcapsules in SGF and SIF were studied. Encapsulation efficiency of LS29 in ACA microcapsules was 99.9%. Approximately 70% of bacteria survived at pH 2 by 120 min after encapsulation. Although not much difference of the survivability of LS29 encapsulated into ACA and FDACA was observed, freeze-drying improved the controlled-release of LS29 in SIF and also showed better storage survivability at 4°C for 8 weeks. Furthermore, investigation of in vitro production of cytokines in RAW264.7 showed high level of induction of TNF-α and IL-10. These In vitro results support that the LS29 might have a balanced immunomodulatory effect.
机译：口服严峻的胃病会导致益生菌的生物利用度低。聚合物封装成功地保护了细菌免受恶劣的胃部状况的侵害，并最终提高了目标区域的持久性和繁殖能力。在这项研究中，我们将LS29封装到ACA微胶囊中并对其进行了表征。研究了SGF和SIF中LS29从载有LS29的ACA微胶囊中的存活和释放。 LS29在ACA微胶囊中的包封率为99.9％。封装后约有70％的细菌在pH 2下存活120分钟。尽管观察到封装在ACA和FDACA中的LS29的存活率差异不大，但冷冻干燥改善了LS29在SIF中的控制释放，并在4°C下显示了8周更好的储存存活率。此外，对RAW264.7中细胞因子的体外产生的研究表明，TNF-α和IL-10的诱导水平很高。这些体外结果支持LS29可能具有平衡的免疫调节作用。

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