Application of acid-catalyzed hydrolysis of dispersed organic solvent in developing new microencapsulation process technology

Honghwa Lee; Sunhwa Lee; Himanshu Bhattacharjee

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Application of acid-catalyzed hydrolysis of dispersed organic solvent in developing new microencapsulation process technology

机译：酸催化水解分散有机溶剂在开发新型微囊化工艺中的应用

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The aim of this study was to evaluate a new microencapsulation technology employing an acid-catalyzed solvent extraction method in conjunction to an emulsion-based microencapsulation process. Its process consisted of emulsifying a dispersed phase of poly(D,L-lactide-co-glycolide) and isopropyl formate in an aqueous phase. This step was followed by adding hydrochloric acid to the resulting oil-in-water emulsion, in order to initiate the hydrolysis of isopropyl formate dissolved in the aqueous phase. Its hydrolysis caused the liberation of water-soluble species, that is, isopropanol and formic acid. This event triggered continual solvent leaching out of emulsion droplets, thereby initiating microsphere solidification. This new processing worked well for encapsulation of progesterone and ketoprofen that were chosen as a nonionizable model drug and a weakly acidic one, respectively. Furthermore, the structural integrity of poly(D,L-lactide-co-glycolide) was retained during microencapsulation. The new microencapsulation technology, being conceptually different from previous approaches, might be useful in preparing various polymeric particles.

机译：这项研究的目的是评估一种新的微囊化技术，该技术采用酸催化的溶剂萃取方法与基于乳液的微囊化工艺相结合。其方法包括在水相中乳化聚（D，L-丙交酯-共-乙交酯）和甲酸异丙酯的分散相。在该步骤之后，向所得的水包油乳液中加入盐酸，以引发溶解在水相中的甲酸异丙酯的水解。它的水解导致释放出水溶性物质，即异丙醇和甲酸。此事件触发了溶剂不断从乳液液滴中浸出，从而引发微球固化。这种新工艺对黄体酮和酮洛芬的封装效果很好，它们分别被选作不可电离的模型药物和弱酸性药物。此外，在微囊化过程中保留了聚（D，L-丙交酯-共-乙交酯）的结构完整性。新的微囊化技术在概念上不同于以前的方法，可能对制备各种聚合物颗粒有用。

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来源
《Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres》 |2012年第4期|共8页
作者
Honghwa Lee; Sunhwa Lee; Himanshu Bhattacharjee;
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原文格式 PDF
正文语种 eng
中图分类药剂学;
关键词
acid-catalysis; microencapsulation; microspheres; PLGA;

机译：酸催化;微囊化;微球;PLGA;

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1. Application of acid-catalyzed hydrolysis of dispersed organic solvent in developing new microencapsulation process technology [J] . Honghwa Lee, Sunhwa Lee, Himanshu Bhattacharjee Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres . 2012,第4期

机译：酸催化水解分散有机溶剂在开发新型微囊化工艺中的应用
2. Nonradiative Energy Transfer between Porphyrin and Copolymer in Films Processed by Organic Solvent and Water-Dispersible Nanoparticles with Photovoltaic Applications [J] . Wouk de Menezes Luana Cristina, Renzi Wesley, do Nascimento Marchiori Cleber Fabiano, The journal of physical chemistry, C. Nanomaterials and interfaces . 2018,第10期

机译：通过具有光伏应用的有机溶剂和水分散纳米粒子加工的薄膜与共聚物之间的非脉状能量转移
3. Exfoliating and Dispersing Few-Layered Graphene in Low-Boiling-Point Organic Solvents towards Solution-Processed Optoelectronic Device Applications [J] . Zhang Lu, Miao Zhongshuo, Hao Zhen, Chemistry, an Asian journal . 2016,第9期

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4. Developing the technology of physicochemicai processing of organic waste in closed life support systems for space applications [C] . A A Tikhomirov, S V Trifonov, E A Morozov International Workshop on Advanced Technologies in Aerospace, Mechanical and Automation Engineering . 2019

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5. The use of new technologies to develop environmentally benign processes: Acid-catalyzed hydrolysis of pinene in aqueous media. [D] . Chamblee, Theresa S. 2004

机译：使用新技术开发对环境无害的方法：在水性介质中pin烯的酸催化水解。
6. Self-healing Microencapsulation of Biomacromolecules without Organic Solvents [O] . Dr. Samuel E. Reinhold, Dr. Kashappa-Goud H. Desai, Dr. Li Zhang, -1

机译：没有有机溶剂的生物致溶剂的自我愈合微胶囊
7. The alkaline hydrolysis of esters in aqueous-organic solvent mixtures. The effects of solvents and of the activity coefficients of reactants on the kinetics of the alkaline hydrolysis of methyl acetate in aqueous dioxan, aqueous dimethyl sulphoxide and aqueous diglyme (bis (2-methoxyethyl ) ether) mixtures as solvents. [O] . Kazempour Abdol Rassoul 1978

机译：水性有机溶剂混合物中酯的碱水解。溶剂和反应物活性系数对乙酸二甲酯，二甲基亚砜水溶液和二甘醇二甲醚（双（2-甲氧基乙基）醚）混合物中乙酸甲酯碱性水解动力学的影响。
8. Water-enhanced solubility of carboxylic acids in organic solvents and its applications to extraction processes [R] . Starr, J. N., King, C. J. 1991

机译：羧酸在有机溶剂中的水溶性增强及其在萃取过程中的应用

Application of acid-catalyzed hydrolysis of dispersed organic solvent in developing new microencapsulation process technology

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