...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Preparation, characterization and anticancer therapeutic efficacy of cisplatin-loaded niosomes
【24h】

Preparation, characterization and anticancer therapeutic efficacy of cisplatin-loaded niosomes

机译：顺铂负载的脂质体的制备，表征和抗癌疗效

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

This study developed a carrier for anticancer drug, cisplatin. Cisplatin-loaded niosomes (CP-NMs) were prepared under optimized conditions with Span 40 and cholesterol as the excipients, and then lyophilized and characterized. Their anticancer efficacy was tested in rabbits bearing VX2 sarcoma. The obtained spherical-looking vesicles showed a diameter of 7.73 ± 1.49 μm with a zero-potential of 0 mV. The entrapment efficiency was 76.93 ±2.67%, and drug loading 2.96 ±0.10%. In vitro release tests gave a t_(50%) of 8,36 h. The rabbits locally injected with the CP-NMs gave significantly superior results of inhibition of tumour growth, much lower mortality and improved results of body weight change and inhibition of tumour metastasis to inguinal lymph nodes and liver compared to those treated in the same way with the drug solution. The inspiring anticancer results indicated that the CP-NMs might be developed as an effective anticancer preparation with low toxicity.
机译：这项研究开发了一种抗癌药物顺铂的载体。在优化条件下，以Span 40和胆固醇作为赋形剂，制备了顺铂负载的脂质体（CP-NMs），然后进行冻干和鉴定。在携带VX2肉瘤的兔子中测试了它们的抗癌功效。所获得的球形囊泡的直径为7.73±1.49μm，零电势为0mV。包封率为76.93±2.67％，载药量为2.96±0.10％。体外释放测试得出t_（50％）为8.36 h。与以相同方式处理的兔子相比，局部注射CP-NMs的兔子在抑制肿瘤生长，降低死亡率和改善体重变化以及抑制肿瘤转移到腹股沟淋巴结和肝脏方面具有明显优越的结果。药物溶液。令人鼓舞的抗癌结果表明，CP-NMs可以作为一种低毒的有效抗癌制剂而开发。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号