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首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >About mean diameter and size distributions of poly(lactide-co-glycolide) (PLG) microspheres
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About mean diameter and size distributions of poly(lactide-co-glycolide) (PLG) microspheres

机译：关于聚丙交酯-乙交酯共聚物（PLG）微球的平均直径和尺寸分布

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摘要

Despite the importance of microsphere size for controlled drug delivery,little work has been done to quantitatively predict the distribution of microspheres from manufacturing techniques.This work presents a quantitative study that describes the size distribution of poly(lactide-co-glycolide) (PLG) microspheres.A fluid mechanics based correlation for the mean microsphere diameter is formulated based on the theory of emulsification in turbulent flow under non-coalescing conditions.The correlation was constructed and validated with experimentally obtained mean microsphere diameters prepared at different stirring speeds.In addition,a Rosin Rammler distribution function was found to give an accurate representation of the microsphere distribution.The spread of the microsphere size distribution was found to decrease with stirring speed.With the validation of the mathematical correlation,it is now possible to have a good estimate of the average microsphere size prior to microsphere preparation.This is directly relevant to the pharmaceutical industry where microspheres of specified mean diameter and size distribution are desirable.
机译：尽管微球尺寸对于控制药物的递送很重要，但仍需要做一些工作来从制造技术上定量预测微球的分布。这项工作提出了定量研究，描述了聚丙交酯-乙交酯（PLG）的尺寸分布在非凝聚条件下，基于湍流乳化理论，建立了基于流体力学的微球平均直径相关性，并建立了相关性并通过在不同搅拌速度下制备的实验性平均微球直径进行了验证。发现Rosin Rammler分布函数可以精确表示微球的分布。发现微球尺寸分布的分布随搅拌速度而减小。通过数学相关性的验证，现在可以对微球制备前的平均微球尺寸n。这直接与需要指定平均直径和尺寸分布的微球的制药行业有关。

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