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首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Emulsification preparation of chitosan-urethane microbeads in the presence of a water-soluble blocked diisocyanate,containing furanone homosyrine lactone bacterial inhibitors
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Emulsification preparation of chitosan-urethane microbeads in the presence of a water-soluble blocked diisocyanate,containing furanone homosyrine lactone bacterial inhibitors

机译:水溶性呋喃酮高丝氨酸内酯细菌抑制剂在水溶性封端二异氰酸酯存在下乳化壳聚糖氨基甲酸酯微珠的制备

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摘要

Chitosan is an abundant naturally occurring biopolymer that is biocompatible,of low toxicity and is well suited as a carrier for a range of active agents.Restrictions imposed by this biopolymers unique solubility requirements make if difficult to process.One approach to an internal setting system is to employ the water-soluble blocked isocyanate hexamethylene-1,6-di(aminocarboxysulphonate) (HDACS) in order to cross-link the chitosan and form microspheres in situ utilizing simple emulsion systems.Chitothane microspheres are capable of delivering active agents at controlled release rates and offers a viable alternative to external set methodologies utilizing aldehydes or similar cross-linking agents.
机译:壳聚糖是一种丰富的天然生物聚合物,具有生物相容性,低毒性,非常适合作为一系列活性剂的载体。这种生物聚合物所施加的限制条件使其难于加工,因此难以加工。内部固化系统的一种方法是为了使用简单的乳液体系使用交联的壳聚糖并原位形成微球,使用水溶性的封闭异氰酸酯六亚甲基-1,6-二(氨基羧基磺酸)六亚甲基酯(HDACS)。壳聚糖微球能够以控制释放的方式递送活性剂率,并为使用醛或类似交联剂的外部固化方法提供了可行的替代方法。

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