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首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Sequential interpenetrating polymer network hydrogel microspheres of poly(methacrylic acid) and poly(vinyl alcohol) for oral controlled drug delivery to intestine
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Sequential interpenetrating polymer network hydrogel microspheres of poly(methacrylic acid) and poly(vinyl alcohol) for oral controlled drug delivery to intestine

机译：聚甲基丙烯酸和聚乙烯醇的顺序互穿聚合物网络水凝胶微球，用于口服控制药物递送至肠道

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Sequential interpenetrating networks of poly(methacrylic acid) and poly(vinyl alcohol) have been prepared and cross-linked with glutaraldehyde to obtain pH sensitive microspheres by a water-in-oil emulsification method. Microspheres have been used to deliver the chosen model anti-inflammatory drug viz., ibuprofen to the intestine. Ibuprofen was encapsulated up to 70% within polymeric matrices. The interpenetrating polymer network formed was analysed by Fourier transform infrared spectroscopy. Differential scanning calorimetry and X-ray diffraction analyses were done on drug-loaded microspheres to confirm the polymorphism of ibuprofen. Results of this study indicated the molecular level dispersion of ibuprofen in the developed microspheres. Scanning electron microscopy confirmed the spherical nature and smooth surfaces of the microspheres produced. Mean particle size of the microspheres as measured by laser light scattering ranged between 51-176μm. Swelling was performed in the simulated gastric as well as the intestinal conditions. Microspheres showed a pulsatile swelling behaviour when pH of the swelling media was altered. The swelling data have been fitted to an empirical equation to understand water transport trends as well as to calculate the diffusion coefficients. Values of diffusion coefficients in acidic media were lower than those found in the basic media. Values of diffusion coefficients decrease with increasing cross-linking of the matrix. In vitro release studies have been performed in 1.2 and 7.4 pH media to simulate the gastric and intestinal conditions. The in vitro release results indicated a dependence on the pH of the release media, extent of cross-linking and the amount of drug loading. The release data were fitted to an empirical relation to estimate the transport parameters and thereby to understand the transport mechanism.
机译：制备了聚甲基丙烯酸和聚乙烯醇的顺序互穿网络，并与戊二醛交联，通过油包水乳化法获得pH敏感的微球。微球已被用于将选择的模型抗炎药即布洛芬递送至肠。布洛芬被封入聚合物基质中的比例高达70％。通过傅立叶变换红外光谱分析形成的互穿聚合物网络。在载药微球上进行了差示扫描量热法和X射线衍射分析，以确认布洛芬的多态性。这项研究的结果表明布洛芬在发达的微球中的分子水平分散。扫描电子显微镜证实了所产生的微球的球形性质和光滑表面。通过激光散射测量的微球的平均粒径在51-176μm之间。在模拟的胃以及肠中进行溶胀。当溶胀介质的pH改变时，微球表现出搏动性溶胀行为。溶胀数据已拟合到经验方程式，以了解水的运输趋势以及计算扩散系数。酸性介质中的扩散系数值低于碱性介质中的扩散系数值。扩散系数的值随着基质交联的增加而降低。已经在1.2和7.4 pH介质中进行了体外释放研究，以模拟胃和肠的状况。体外释放结果表明取决于释放介质的pH，交联程度和载药量。将释放数据与经验关系进行拟合，以估算运输参数，从而了解运输机理。

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