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首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Encapsulation of Fe3O4 in gelatin nanoparticles:Effect of different parameters on size and stability of the colloidal dispersion
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Encapsulation of Fe3O4 in gelatin nanoparticles:Effect of different parameters on size and stability of the colloidal dispersion

机译：Fe3O4在明胶纳米粒子中的包封：不同参数对胶体分散体尺寸和稳定性的影响

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Encapsulation of magnetite(IOPs)in gelatin nanoparticles has been carried out by in situ precipitation of the particles in presence of gelatin,followed by desolvation and cross-linking of the composite nanoparticles.The aim of the study was to investigate the effect of various formulation parameters(viz;desolvating agent,cross-linking agent and percentage of IOPs)on the hydrodynamic size of the gelatin-coated magnetic iron oxide composite nanoparticles(GIOPs)and stability of the colloidal dispersion.Extensive characterization by dynamic light scattering,thermogravimetric analysis,X-ray diffraction,infrared spectroscopy,transmission electron microscopy and atomic force microscopy shows complete encapsulation of IOPs of size below 8 nm into gelatin nanoparticles of varying size.Size as well as stability of the colloidal dispersion of the GIOPs was found to be dependent on the investigated parameters.Furthermore,the nanoparticle dispersion was found to be stable in pH ranges from 2-12.Thus,obtained composite nanoparticles could hold promise as a carrier system in biomedical applications.
机译：通过在明胶存在下原位沉淀颗粒，然后通过复合纳米颗粒的去溶剂化和交联，将磁铁矿包裹在明胶纳米颗粒中。研究的目的是研究各种制剂的效果明胶包覆的磁性氧化铁复合纳米颗粒（GIOPs）的流体力学尺寸和胶体分散体的稳定性的参数（即脱溶剂，交联剂和IOPs的百分比）。动态光散射，热重分析的广泛表征X射线衍射，红外光谱，透射电子显微镜和原子力显微镜显示大小小于8 nm的IOP完全封装到大小不同的明胶纳米颗粒中。发现GIOP的大小和胶体分散体的稳定性取决于此外，发现该纳米颗粒分散体在2-12的pH范围内是稳定的。因此，获得的复合纳米颗粒有望在生物医学应用中作为载体系统。

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