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首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Evaluation of alkyl polyglucoside as an alternative surfactant in the preparation of peptide-loaded nanoparticles
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Evaluation of alkyl polyglucoside as an alternative surfactant in the preparation of peptide-loaded nanoparticles

机译：在制备载有肽的纳米颗粒中评价烷基多糖苷作为替代表面活性剂

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摘要

The present study was carried out to evaluate potentials of alkyl polyglucoside (APG) as an alternative surfactant/stabilizer in the preparation of peptide-loaded nanoparticles. hGF2 (human gel filtration fraction 2) was used as a model peptide and APG based on C_(10) fatty alcohol (decyl polylglucoside) was used as a representative surfactant. PLA (poly D,L-lactide) and PLGA (poly D,L-lactide-co-glycolide) based nanoparticles were prepared and the effect of APG on particle size, entrapment efficiency and biological activity was evaluated. At a concentration as low as 0.05% w/v, APG provided an excellent stabilization effect, resulting in nanoparticles with better encapsulation efficiency and particle size well below 450 nm. The effective concentration of APG was found to be much less (10-fold) as compared to PVA. Moreover, APG also showed low residual content as compared to PVA. In-vitro and in-vivo biological activity evaluation confirmed that encapsulated peptide was compatible with APG. These preliminary results suggest that APGs can be used as alternate surfactants for nanoparticle preparation.
机译：进行本研究以评估烷基聚葡糖苷（APG）作为替代表面活性剂/稳定剂在制备载有肽的纳米颗粒中的潜力。将hGF2（人凝胶过滤级分2）用作模型肽，并将基于C_（10）脂肪醇（癸基聚葡糖苷）的APG用作代表性表面活性剂。制备了基于PLA（聚D，L-丙交酯）和PLGA（聚D，L-丙交酯-乙交酯）的纳米颗粒，并评估了APG对粒径，包封率和生物活性的影响。在低至0.05％w / v的浓度下，APG提供了出色的稳定效果，从而使纳米颗粒具有更好的包封效率，且粒径远低于450 nm。发现与PVA相比，APG的有效浓度要低得多（10倍）。此外，与PVA相比，APG还显示出较低的残留含量。体外和体内生物学活性评估证实了包封的肽与APG相容。这些初步结果表明，APG可用作纳米颗粒制备的替代表面活性剂。

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