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首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Optimization of formulation variables for the development of long acting microsphere based depot injection of olanzapine
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Optimization of formulation variables for the development of long acting microsphere based depot injection of olanzapine

机译：优化基于长效微球的奥氮平长效注射剂开发的配方变量

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摘要

This work was aimed to optimize the composition of microspheres of olanzapine to design long acting depot injection for the treatment of psychosis. Solvent evaporation method was used for the fabrication of microspheres. Different formulation variables for the solvent evaporation method, viz., effect of theoretical drug loading, type of surfactant and its concentration, temperature, volume of external phase and presence of salt in external aqueous phase, conditions and time of solvent evaporation and drying methodology were optimized. The microspheres were characterized for encapsulation efficiency, particle size, surface morphology, residual solvent content, drug release profile and drug release kinetics. The optimized formulation showed consistent drug release for upto 14 days time period.
机译：这项工作旨在优化奥氮平微球的组成，以设计长效长效注射剂来治疗精神病。溶剂蒸发法用于微球的制备。溶剂蒸发方法的不同配方变量，即理论药物载量，表面活性剂类型及其浓度，温度，外相体积和外部水相中盐的存在，溶剂蒸发和干燥方法的条件和时间的影响是优化。对微球的包封效率，粒度，表面形态，残留溶剂含量，药物释放曲线和药物释放动力学进行了表征。优化的配方在长达14天的时间内显示出一致的药物释放。

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