...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Development of an oral microemulsion formulation of alendronate: Effects of oil and co-surfactant type on phase behaviour
【24h】

Development of an oral microemulsion formulation of alendronate: Effects of oil and co-surfactant type on phase behaviour

机译：阿仑膦酸酯口服微乳制剂的开发：油和助表面活性剂类型对相行为的影响

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

This study aimed to prepare a water-in-oil microemulsion formulation of alendronate. Pseudo-ternary phase diagrams were constructed by using different oils and co-surfactants. The final formulation was decided to be prepared with Captex 200~R, lecithin, propylene glycol and bidistilled water. Rheological behaviour, phase stability and type of the microemulsion formulation were investigated by Brookfield viscosimeter, centrifugation test and dye method, consequently. Phase behaviour of the formulation was found to be Newtonian. No precipitation was observed in the stressed conditions and formulation was W/O. The physical characterization of the formulation (physical appearance, viscosity, refractive index, conductivity, density and turbidity) was investigated at 4°C and 25°C during 6 months while droplet size was investigated for 3 months. Droplet size of the formulation was between 224—280 nm while viscosity was between 89.9-99.5 mPa.S. The release of alendronate from the microemulsion formulation was examined by dialysis method and found to be 97.2% at the end of 7 h. None of the parameters except refractive index changed significantly during the determined periods. This study succeeded in preparing a stable microemulsion formulation of alendronate.
机译：这项研究旨在制备阿仑膦酸盐的油包水微乳液配方。通过使用不同的油和助表面活性剂构建了伪三元相图。最终配方决定用Captex 200R，卵磷脂，丙二醇和双蒸馏水制备。因此，通过布鲁克菲尔德粘度计，离心测试和染色方法研究了微乳液制剂的流变行为，相稳定性和类型。发现该制剂的相行为是牛顿的。在压力条件下未观察到沉淀，且配方为W / O。在6个月内于4℃和25℃下研究了制剂的物理特性（物理外观，粘度，折射率，电导率，密度和浊度），同时对液滴尺寸进行了3个月的研究。制剂的液滴尺寸在224-280nm之间，而粘度在89.9-99.5mPa.S之间。通过透析方法检查了阿仑膦酸盐从微乳液制剂中的释放，并且在7小时结束时发现为97.2％。在确定的时间段内，除折射率外，所有参数均无显着变化。该研究成功制备了稳定的阿仑膦酸盐微乳液制剂。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号